Fatigue in Healthy Individuals
This protocol is designed to characterize the symptoms of fatigue in healthy individuals
using standardized questionnaires and determine if physical activity, pain, depression,
catastrophizing, stress, and daytime sleepiness play a role in the experience. This study
will also examine the potential role of plasma cytokines and hypothalamic-pituitary-adrenal
axis (HPA) functioning in symptoms of fatigue in healthy individuals.
Eligible participants will complete questionnaires that measure fatigue, pain, depression,
fatigue catastrophizing, perceived stress, daytime sleepiness, neurological health, and
physical activity. Participants will also perform strength testing (e.g. hand grips), walk
testing (6-minute walk test), exercise testing on a treadmill, and physical activity
monitoring using a portable activity device. Blood samples will be obtained to determine
cytokine profiles, gene expression, and levels of stress hormones (cortisol,
dehydroepiandrosterone [DHEA], catecholamines). Urine samples will also be obtained to
measure the levels of stress hormones excreted. Information collected in this protocol will
be used to make comparison in subjects who experience extreme symptoms of fatigue due to
many different disorders, in order to better understand the mechanisms of fatigue.
Time Perspective: Prospective
The primary outcome of the study is the fatigue score of healthy individuals using standardized questionnaires.
Leorey N Saligan, C.R.N.P.
National Institute of Nursing Research (NINR)
United States: Federal Government
|National Institutes of Health Clinical Center, 9000 Rockville Pike||Bethesda, Maryland 20892|