Inclusion Criteria:

- Subject previously treated with CS7017 as part of a study that included CS7017 and
has shown clinical benefits from treatment with CS-7017.

Exclusion Criteria:

- Anticipation of need for a major surgical procedure or radiation therapy during the
study.

- Any of the following conditions within 6 months prior to initiating study treatment:
Myocardial infarction with significant impairment of cardiac function (eg, ejection
fraction ≤ 50%), severe/unstable angina pectoris, coronary/peripheral artery bypass
graft, NYHA class II or higher congestive heart failure.

- Subjects with clinically significant pleural or pericardial effusions.

- Clinically significant active infection, which requires antibiotic therapy, or
HIV-positive subjects receiving antiretroviral therapy.

- Subjects with diabetes mellitus requiring treatment with insulin, sulfonylureas or
TZDs agents, malabsorption syndrome, chronic diarrhea, inflammatory bowel disease, or
partial bowel obstruction.