Efficacy of Caffeine as an Adjuvant to Opioid Therapy in Cancer Pain: a Randomized, Double-blind, Placebo-controlled Trial
Previous studies on cancer pain lacked assessment of quality of life. And most of previous
studies on cancer pain did not give attention to symptoms accompanied with pain. We include
such variables as outcome measures, and aimed to evaluate the efficacy and the safety of
intravenous caffeine in advanced cancer inpatients.
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Supportive Care
Numeric Rating of Scale (From 0 to 10) of Pain and Possible Side Effects (Drowsiness, Confusion, Nausea) of Opioids
Scores were measured by Numeric Rating Scale. Scores range from 0 to 10; higher scores represent higher levels of pain, and possible side effects (drowsiness, confusion, nausea) of opioids.
Sang-Yeon Suh, M.D.,Ph.D
Korea: Food and Drug Administration