Inclusion Criteria:

- Patients confirmed Hodgkin's lymphoma at refractory at first line therapy, relapse
early or late;

- Age > 18 years;

- Life expectancy > 3 months;

- Cardiac, pulmonary, renal and liver functions with normal range;

- Written informed consent.

Exclusion Criteria:

- Any psychological, familiar or geographical conditions that could potentially hinder
the compliance to the protocol;

- renal failure as creatinine> 1.2 mg/dl or creatinine clearance <60 ml/min;

- AST/ALT or bilirubin> 2.5 times the norm;

- HCV positivity with signs of ongoing viral replication (HCV PCR + AST>1.5-2x normal);

- Heart disease clinically significant: eg. severe hypertension not controlled,
multifocal uncontrolled cardiac arrhythmias, symptomatic ischemic heart disease or
congestive heart failure class NYHA class III-IV (Annex 2), previous acute myocardial
infarction;

- Ventricular ejection fraction <45%;

- decompensated diabetes mellitus not controlled by insulin therapy; Disease with
significant pulmonary function defined as FEV1 <65% of predicted or DLCO <50% of
predicted value;

- HIV positive patients;

- Patients with uncontrolled infection;

- Neoplasia in the last 3 years except carcinoma in situ uterus, neck and basal skin
cancer or prostate cancer in early stage localized exeresi treated with surgery or
brachytherapy with curative intent, a good prognosis DCIS breast treated with surgery
alone;

- Drug addiction or alcoholism.