Inclusion Criteria:

- Biopsy proven mantle cell lymphoma

- Patients who are refractory to their regimen or have relapsed once, twice or up to
three times and who have documented progressive disease

- Eastern Cooperative Oncology Group (ECOG) performance score 0,1, or 2

- Willing to follow pregnancy precaution

Exclusion Criteria:

- Any of the following laboratory abnormalities

- Absolute neutrophil count (ANC)<1,500 cells/mm^3 (1.5 x 10^9/L)

- Platelet count < 60,000/mm^3 (60 x 10^9/L)

- Serum aspartate transaminase/Serum glutamic oxaloacetic transaminase(AST/SGOT) or
Alanine transaminase/Serum glutamic pyruvic transaminase (ALT/SGPT) >3.0 x upper
limit or normal (ULN), except patients with documented liver involvement by lymphoma

- Serum total bilirubin > 1.5 x ULN, except in case of Gilbert's Syndrome and
documented liver involvement by lymphoma.

- Calculated creatinine clearance (Cockcroft-Gault formula) of < 30 mL/min

- History of active central nervous system (CNS) lymphoma within the previous 3 months

- Subjects not willing to take Deep venous thrombosis (DVT) prophylaxis

- Known seropositive for or active viral infection with human immunodeficiency virus
(HIV), hepatitis B virus (HBV) or hepatitis C virus (HCV). Patients who are
sero-positive because of hepatitis B virus vaccine are eligible