Modifications of Hormone Receptors and Biological Parameters of Metastatic Breast Cancer Treated With First-line Chemotherapy. Prospective Biological Study.
- Evaluate the effect of first-line chemotherapy on expression of hormone receptors and
biomarkers in women with metastatic breast cancer.
- Assess changes in HER1 and HER2 expression during treatment.
OUTLINE: This is a multicenter study.
Patients receive 6-9 courses of front-line chemotherapy according to the investigator.
Patients with estrogen receptor- and/or progesterone receptor-positive disease receive
Patients undergo biopsy prior to and after completion of chemotherapy for examination of
hormone receptors and HER1 and HER2 expression.
After completion of study treatment, patients are followed every 6 months for 5 years.
Primary Purpose: Treatment
Changes in hormone receptor expression
Philippe Chollet, MD, PhD
Centre Jean Perrin
United States: Federal Government