Photodynamic Therapy With S-1 in the Patients With Unresectable Type III or IV Cholangiocarcinoma: A Prospective Randomized Trial With Open Label Control
In patients with unresectable perihilar cholangiocarcinoma, photodynamic therapy with
biliary stent has been known for palliation of jaundice and improving survival. But most of
therapeutic effects were expected to delay bile duct obstruction rather than to decrease the
tumor. Recently orally available chemotherapeutic agent, S-1 was reported as effective in
patients with bile duct adenocarcinoma. The investigators' aims of study evaluate the
combined effect of photodynamic therapy and S-1.
Interventional
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment
Compare overall survival time in patients with unresectable perihilar cholangiocarcinoma treated with photodynamic therapy combined with or without S-1
12 months after study start
Yes
Do Hyun Park, MD, PhD
Principal Investigator
Asan Medical Center
Korea: Food and Drug Administration
2009-0056
NCT00869635
February 2009
August 2013
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