Inclusion Criteria:

- Confirmed metastatic or unresectable, resistant solid tumor. Gynecologic tumors
preferred.

- 18 years and above

- GOG performance status greater than or equal to 2

- Life expectancy greater than 6 months

- Acceptable organ and marrow function

- Willingness to agree to use adequate contraception prior to study entry and for the
duration of study participation

Exclusion Criteria:

- Chemotherapy or radiotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin C)
prior to entering the study or have not recovered from adverse events due to agents
administered more than 4 weeks earlier

- Not receiving any other investigational agents

- Known brain metastasis

- Uncontrolled intercurrent illness including, but not limited to ongoing ore active
infection, symptomatic congestive heart failure, unstable angina pectoris,cardiac
arrythmia, or psychiatric illness/social situations that would limit compliance with
study requirements

- Pregnancy

- Immunosuppression including subjects with known HIV infection on immunosuppressive
drugs or having an autoimmune disorder

- Penicillin allergy

- Symptomatic prostate hypertrophy