Intra-arterial (Ophthalmic Artery) Chemotherapy for Retinoblastoma
N/A
N/A
Both
Retinoblastoma
Trial Information
Intra-arterial (Ophthalmic Artery) Chemotherapy for Retinoblastoma
The management of retinoblastoma includes systemic chemotherapy (carboplatin, etoposide, and
vincristine), thermotherapy, cryotherapy (freezing treatment), laser photocoagulation,
plaque radiotherapy, external beam radiotherapy, and enucleation. The treatment is tailored
to each individual case. Over the past 15 years, intravenous chemotherapy has risen as the
most popular conservative (eye-saving) method for retinoblastoma management because it is
effective and safe. In recent years, there has been keen interest in providing chemotherapy
more focally to a diseased organ including the liver, brain, and eye. The benefit of focal
chemotherapy delivery is to avoid toxicity to other organs and this toxicity includes the
risk of future cancers.
Inclusion Criteria:
- Advanced retinoblastoma in one or both eyes
- Recurrent retinoblastoma after failure of previous treatment
- No age limit (usually kids presenting with retinoblastoma present in the 1st two
decades of life)
- Judged by principal investigator to be medically and physically able to undergo the
procedure
Exclusion Criteria:
- Recurrent retinoblastoma which is treatable with other conservative measures
- Invasive retinoblastoma (retinoblastoma that has grown locally outside of the eye,
for example, into the bone around the eye)
Type of Study:
Interventional
Study Design:
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Outcome Measure:
Tumor control
Outcome Time Frame:
after 5 cycles of chemotherapy
Safety Issue:
Yes
Principal Investigator
Carol L Shields, MD
Investigator Role:
Principal Investigator
Investigator Affiliation:
Oncology Service, Wills Eye Institute
Authority:
United States: Food and Drug Administration
Study ID:
08-885
NCT ID:
NCT00857519
Start Date:
January 2009
Completion Date:
April 2014
Related Keywords:
- Retinoblastoma
- retinoblastoma
- Intraarterial
- Chemotherapy
- Melphalan
- Carboplatin
- Retinoblastoma
Name | Location |
|---|---|
| Oncology Service, Wills Eye Institute | Philadelphia, Pennsylvania 19107 |
