Inclusion Criteria

DISEASE CHARACTERISTICS:

- Histologically or cytologically confirmed metastatic adenocarcinoma of the breast

- Malignant disease in the skin, chest wall, or other sites (lymph nodes or
primary tumor in the breast) accessible to percutaneous needle placement and
injection

- Solitary or multiple tumors

- Measurable disease in ≥ 2 dimensions by physical examination or CT/MRI scan

- Malignant tumors in the skin and chest wall must be ≥ 4 mm in diameter by
physical examination

- Malignant tumors in other accessible sites must be ≥ 1 cm in diameter on
physical examination

- Malignant disease in other organs (in addition to skin or chest wall metastases)
allowed

- Hormone receptor status not specified

PATIENT CHARACTERISTICS:

- Menopausal status not specified

- Karnofsky performance status 70-100%

- Life expectancy ≥ 16 weeks

- Granulocyte count ≥ 1,500/mm^3

- Platelet count ≥ 100,000/mm^3

- Hemoglobin ≥ 9.0 mg/dL

- PT normal

- Serum creatinine ≤ 1.5 mg/dL OR creatinine clearance ≥ 45 mL/min

- Serum total bilirubin ≤ 2.0 times upper limit of normal (ULN)

- Serum transaminases ≤ 2.5 times ULN

- Not pregnant or nursing

- Negative pregnancy test

- Weight ≥ 30 kg (for patients treated with the highest dose level of study drug)

- No active infection or concurrent serious medical illness

- No HIV positivity

- No other malignancy within the past 5 years except for the following:

- Inactive nonmelanoma skin cancer

- In situ carcinoma of the cervix

- Grade 1 papillary bladder cancer

PRIOR CONCURRENT THERAPY:

- More than 4 weeks since prior chemotherapy (6 weeks for nitrosoureas)

- No anticoagulant therapy with heparin or warfarin for ≥ 2 months after completion of
study treatment