Inclusion Criteria:

- female patients, >=18 years of age;

- breast cancer, with measurable, locally recurrent or metastatic lesions, or patients
with bone metastasis only;

- HER2-negative disease;

- candidates for chemotherapy;

- ECOG PS of <=2;

Exclusion Criteria:

- previous chemotherapy for metastatic or locally advanced breast cancer;

- previous radiotherapy for treatment of metastatic breast cancer;

- any prior adjuvant treatment with anthracyclines completed <6 months prior to
enrolment;

- chronic daily treatment with corticosteroids (>=10mg/day) aspirin (>325mg/day) or
clopidogrel (>75mg/day);