Inclusion Criteria:

1. Written informed consent.

2. Age: 18-75 years.

3. Male or non-pregnant, non-lactating female.

4. a.Pancreatic cancer: Histologically or cytologically confirmed diagnosis, stage IVA
or IVB (AJCC, 1997).

b. Melanoma: Histologically or cytologically confirmed diagnosis, stage III or IV
(AJCC, UICC).

c. Colorectal cancer: Histologically or cytologically confirmed diagnosis, stage III
or IV (AJCC, UICC), excluded from the last cohort.

5. Patient is not or no longer amenable to established forms of therapy.

6. At least one measurable lesion.

7. Karnofsky performance status of at least 80%.

8. Recovery from acute toxicity caused by any previous therapy.

9. Adequate organ function as assessed by the following laboratory values:

- Serum creatinine and urea < 2 times the upper limit of normal (ULN).

- ALT and AST < 3 ULN (in case of a liver metastasis: < 5x ULN); alkaline
phosphatase < 3 ULN; and bilirubin < 2.5 mg/dL.

- Prothrombin time < 1.5 INR and PTT < 1.5 times the upper limit of normal.

- Hemoglobin > 9 g/dL.

- Platelets > 100 x 10E9/L.

- WBC > 3.0 x 10E9/L.

- Absolute Neutrophil Count (ANC) > 1.5 x 10E9/L.

Exclusion Criteria:

1. Patient unable to comply with the protocol regulations.

2. Pregnant or lactating female.

3. Antitumor radiation therapy within 12 weeks, tumor surgery within 4 weeks or any
other therapy with established antitumor effects within 2 weeks prior to study entry.

4. The patient takes or is likely to need other prohibited concomitant medication.
Administration of corticosteroids should be strictly avoided during the course of the
study.

5. Patient's participation in another clinical trial with investigational medication
within 30 days prior to study entry.

6. History of brain metastases. In the case of suspected brain metastases a CT scan of
the skull will be performed (not mandatory in asymptomatic patients).

7. Clinically significant cardiovascular abnormalities such as refractory hypertension,
congestive heart failure, unstable angina, or poorly controlled arrhythmia, or a
myocardial infarction within 6 months prior to treatment.

8. Gastric or duodenal ulcers within 6 months before study entry or is at risk of
gastrointestinal ulceration due to high consumption of NSAIDs.

9. An active infection with HIV, HBV, or HCV.

10. Clinically significant acute viral, bacterial, or fungal infection.

11. Acute medical problems that may be considered to become an unacceptable risk, or any
conditions that might be contraindications for starting study treatment.

12. History of allergies to reagents used in this study.

13. Drug abuse or extensive use of alcohol.

14. Significant psychiatric disorders/ legal incapacity or limited legal capacity.

15. History of Long QT Syndrome or QTc time ≥ 480 msec in screening/baseline ECGs. The
average QTc time is to be calculated from three separate ECGs performed prior to
start of infusion: two ECGs performed at Screening/Baseline (with a minimum 1-hour
interval in between) and one performed within 1 hour prior to start of infusion.