The Effects of Adding a Home Exercise Program (HEP) to a Clinical Physical Therapy Program (CPTP) on the Cancer-Related Fatigue Reported by Patients Undergoing Concurrent Radiation and Chemotherapy for High-Grade Glioma (HGG)
Cancer-related fatigue is a common and disabling symptom in patients undergoing outpatient
therapies to treat their cancers. Despite a consistent increase in both awareness and
research, cancer-related fatigue remains poorly understood and poorly treated by the
worldwide medical community.
The physical and emotional impact of cancer-related fatigue on Activities of Daily Living
and Independent Activities of Daily Living can be profound. Simple tasks such as preparing
meals and performing household chores become laborious. Walking up and down the aisles of
grocery stores may send a patient directly to bed for the rest of the day upon returning
home. In addition, if cancer-related fatigue contributes to prolonged bed rest, the
secondary development of other medical problems can further impact quality of life and
possibly length of life. Furthermore, the economic impact of cancer-related fatigue includes
patients taking more days off work and reducing the number of hours they are able to work.
Lastly, cancer-related fatigue often impacts the psychosocial well-being and family dynamics
of patients, caregivers and their families.
Exercise is the strongest non-pharmacological intervention for management of cancer-related
fatigue. Certain exercises have specifically demonstrated reduction in fatigue. An exercise
program that incorporates strengthening and aerobic conditioning can decrease fatigue
scores. Improvements in patient-reported cancer-related fatigue through the use of exercise
has been demonstrated in various diseases, such as anemia, and several cancer types, most
notably breast cancer. Furthermore, home exercise programs have shown meaningful
improvements in patient reported fatigue.
This study will determine the effect that the addition of a 6-week Physical
Therapist-directed home exercise program has on the pattern, severity, and quality of life
of patient reported fatigue.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment
Determine the effect of a 6-week Physical Therapist-directed home exercise program on the pattern of patient reported fatigue.
Erin M Dunbar, MD
University of Florida
United States: Institutional Review Board
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