Inclusion Criteria

Inclusion criteria :

- age ≥ 18 years

- an informed consent is obtained

- patients with anatomy-pathologically proved melanoma

- the tissue sample of melanoma is available

- the primary melanoma is treated according to the international standard

- absence of a progressive non neoplastic pathology involving life-threatening

- patient living in Ile de France region.

- time limit to entry in the cohort must be:

- within 3 months after Surgical resumption of primary melanoma;

- within 3 months after curative surgical treatment;

- with one month after diagnosis of a transit metastasis or a distant metastasis.

Exclusion criteria :

- refusal of the patient

- pathology sample isn't available

- primary melanoma not being treated according to the international standard

- patient living too far to follow regular visits

- patient diagnosed with a progressive non neoplastic pathology involving
life-threatening

- too late to entry and lack of useful stored specimens to research.