Endometrial Local Injury Improves the Pregnancy Rate Among Recurrent Implantation Failure Patients Undergoing IVF/ICSI
15 Years
39 Years
Female
Infertility
Trial Information
Endometrial Local Injury Improves the Pregnancy Rate Among Recurrent Implantation Failure Patients Undergoing IVF/ICSI
In a randomized control trial study, 93 women with at least two implantation failures were
evaluated. In case group endometrial biopsy was obtained from 48 patients in the luteal
phase of previous cycle and implantation and clinical pregnancy rate were compared with 45
patients in control group.
The implantation rate was determined as 10.9% in biopsy group compared with 3.38% in
controls. Clinical pregnancy rate was significantly higher in case group than controls
(27.1% and 8.9% respectively
Inclusion Criteria:
- women with recurrent implantation failure which was defined as 2-6 cycles
unsuccessful of IVF-ET in which more than 10 high grade embryo were transferred
Exclusion Criteria:
- age over than 40 years old
- poor responders to ovarian stimulation
Type of Study:
Interventional
Study Design:
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment
Outcome Measure:
Implantation Rate,Chemical pregnancy rate, Clinical pregnancy rate
Outcome Time Frame:
One year
Safety Issue:
Yes
Principal Investigator
Mohammad Ali Karimzadeh, Professor
Investigator Role:
Principal Investigator
Investigator Affiliation:
Research and Clinical Center for Infertility
Authority:
Iran: Ministry of Health
Study ID:
1551354
NCT ID:
NCT00837733
Start Date:
January 2008
Completion Date:
December 2008
Related Keywords:
- Infertility
- Endometrial biopsy
- IVF/ICSI
- Pregnancy outcome
- Recurrent implantation failure
- Infertility
- Adenoma
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