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A Pilot Study of Exercise in Men With Prostate Cancer Receiving Androgen Depletion Therapy

50 Years
Not Enrolling
Prostate Cancer

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Trial Information

A Pilot Study of Exercise in Men With Prostate Cancer Receiving Androgen Depletion Therapy

Inclusion Criteria:

- men aged 50 years or older

- diagnosed with adenocarcinoma prostate cancer

- will initiate and receive continuous ADT (luteinizing hormone releasing hormone
agonist (LHRH) or combination of LHRH and anti-androgen) for at least 12 months after

- Patients will also consent to participating in the study.

Exclusion Criteria:

- severe cardiac disease (New York Heart Association class III or greater)

- angina

- severe osteoporosis

- uncontrolled hypertension (blood pressure > 160/95mm Hg)

- orthostatic blood pressure drop > 20mm Hg

- moderate to severe aortic stenosis

- acute illness or fever

- uncontrolled atrial or ventricular dysrhythmias

- uncontrolled sinus tachycardia (> 120 beats per minute)

- uncontrolled congestive heart failure third-degree atrio-ventricular heart block,
active pericarditis or myocarditis, recent embolism, thrombophlebitis, deep vein
thrombosis, resting ST displacement (> 3mm), uncontrolled diabetes, uncontrolled
pain, cognitive impairment, history of falls due to balance impairment or lost of
consciousness, severe neuromusculoskeletal conditions that limit their ability to
perform walking exercise (including ataxia, peripheral or sensory neuropathy,
unstable bone lesion, severe arthritis, pathological lower limb fractures within 6
months, lower limb amputation).

Type of Study:


Study Design:

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment

Outcome Measure:

bone health

Outcome Time Frame:

baseline, 12 months

Safety Issue:


Principal Investigator

C. Ellen Lee, PhD, PT

Investigator Role:

Principal Investigator

Investigator Affiliation:

University of Manitoba


Canada: Ethics Review Committee

Study ID:




Start Date:

October 2008

Completion Date:

December 2010

Related Keywords:

  • Prostate Cancer
  • Prostatic Neoplasms