Inclusion Criteria:

- Multiple Myeloma stage II/III Durie and Salmon

- Patients without preceding cytostatic treatment, however, pretreatment with
dexamethasone is allowed

- Written informed consent

- Female patients have to be postmenopausal or surgically sterilized or willing to use
an acceptable method of birth control (i.e.1 hormonal contraceptives, intrauterine
device, diaphragm with spermicide, total abstinence or a vasectomised partner) during
and 6 months after the treatment, pregnancy test has to be negative

- Male patients have to use an acceptable method of birth control during and 6 months
after the treatment

- males should be offered sperm cryoconservation

- Karnofsky performance status >= 60%

- AST and ALT < 2.5 x the upper limit of normal (ULN)

- Bilirubin < 2.5 x the upper limit of normal (ULN)

- Adequate haematological parameters: leucocytes >= 3.0 x 109/l, neutrophils >= 1.5 x
109/l, platelets >= 75 x 109/l

- Creatinin < 2 x the upper limit of normal (ULN)

Exclusion Criteria:

- Non-secretory multiple myeloma

- known allergy or hypersensitivity to bortezomib, bor, mannitol, cyclophosphamide

- Estimated life expectancy less than 3 months

- History of cancer (except basal cell carcinoma) in the last 5 years

- Patients with history of peripheral neuropathy CTC grade >= 2

- Other severe illnesses that could potentially interfere with the completion of
treatment according to this protocol: a. Insufficient liver or renal function,
clinically relevant lung disease or gastrointestinal diseases, b. New York Heart
Association (NYHA) > Class II heart failure, myocardial infarction within 6 months of
enrollment, uncontrolled angina, severe uncontrolled ventricular arrhythmias (Lown
IVB), electrocardiographic evidence of acute ischemia or active conduction system
abnormalities, cardiac amyloidosis, c. Active systemic infection requiring treatment,
d. Poorly controlled hypertension or vascular disease. Diabetes mellitus, or other
serious endocrine or metabolic diseases

- Patients with hypotension (defined as RRsys sitting <= 100 mmHg and/or RRdia sitting
<= 60 mmHg

- HIV positive patients

- Patients with active hepatitis B and/or C

- Pregnant or breast-feeding female patients

- Insufficient compliance, foreseeable follow-up problems, psychiatric diseases, known
abuse of alcohol or drugs, legal incompetence

- Participation in another trial either parallel to this trial or within the last 30
days before enrollment into this trial

- except drug studies for relapse in the observation period.