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Randomized Clinical Trial for Treatment of Meibomian Gland Dysfunction and Evaporative Dry Eye

18 Years
Not Enrolling
Chalazion, Dry Eye Syndromes

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Trial Information

Randomized Clinical Trial for Treatment of Meibomian Gland Dysfunction and Evaporative Dry Eye

Inclusion Criteria:

- At least 18 years of age.

- Meibomian gland obstruction

- Dry eye symptoms

- Willingness to comply with study procedures and return for all visits

Exclusion Criteria:

- Ocular surgery, injury, or herpes infection within past 3 months

- Active ocular infection

- Active ocular inflammation or recurrent inflammation within past 3 months

- Moderate to severe allergic conjunctivitis

- Severe eyelid inflammation

- Eyelid abnormalities that affect lid function

- Ocular surface abnormalities that may compromise corneal integrity

- Macular disease

- Systemic disease condition or medication that causes dry eye

- Use of other treatments for meibomian gland dysfunction or dry eye

- Pregnant or nursing women

- Participation in another ophthalmic clinical trial within past 30 days

Type of Study:


Study Design:

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Meibomian Gland Assessment (Total Meibomian Gland Secretion Score)

Outcome Description:

Evaluation of secretion characteristics from the gland orifices along the lower eyelid. Assessment was based on the grading scale: 3 (clear liquid secretion), 2 (cloudy liquid secretion), 1 (inspissated), 0 (no secretion). The total meibomian gland secretion score was the sum of the grades for all 15 glands with a range of 0 to 45.

Outcome Time Frame:

Baseline, 2 Weeks and 4 Weeks

Safety Issue:


Principal Investigator

Christy Stevens, OD

Investigator Role:

Study Director

Investigator Affiliation:

TearScience, Inc.


United States: Institutional Review Board

Study ID:




Start Date:

February 2009

Completion Date:

August 2009

Related Keywords:

  • Chalazion
  • Dry Eye Syndromes
  • Chalazion
  • Dry Eye Syndromes
  • Keratoconjunctivitis Sicca



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