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Anatomical Segmental and Subsegmental Resection of the Liver for Hepatocellular Carcinoma: a New Approach by Means of Ultrasound-Guided Vessel Compression


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Hepatocellular Carcinoma

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Trial Information

Anatomical Segmental and Subsegmental Resection of the Liver for Hepatocellular Carcinoma: a New Approach by Means of Ultrasound-Guided Vessel Compression


We herein describe a novel technique for the demarcation of the resection area by means of
IOUS-guided finger compression to systematically accomplish anatomical segmental and
subsegmental resections.

Using the IOUS, the tumor and the level targeted for compression are identified. Than, under
the IOUS guidance, the surgeon compresses bilaterally the liver at the targeted position
resulting in the compression of the portal pedicle feeding the tumor previously identified.
This maneuver is constantly monitored in real-time just using the same microconvex probe,
and it is maintained until the surface of the targeted liver area begins to discolor, at
that time the first assistant marks the discolored area with the electrocautery, and the
compression is released. Once the area is demarcated, liver dissection is started under
intermittent Pringle's maneuver.


Inclusion Criteria:



- Patients suitable for surgical approach carries of HCC

- Serum bilirubin level lower than 1.5 mg/dl

Exclusion Criteria:

- Presence of ascites

- Serum bilirubin level equal or higher than 1.6 mg/dl

- Conditions (size, vascular relation, or infiltration) demanding resection larger than
a segmental area

- Tumor thrombus in portal or hepatic veins

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

Technical feasibility

Safety Issue:

No

Principal Investigator

GUIDO TORZILLI, MD, PHD

Investigator Role:

Study Chair

Investigator Affiliation:

University of Milan

Authority:

Italy: Ministry of Health

Study ID:

IOUS-COMP GENERAL

NCT ID:

NCT00829335

Start Date:

January 2007

Completion Date:

January 2009

Related Keywords:

  • Hepatocellular Carcinoma
  • Intraoperative ultrasound
  • Segmentectomy
  • HCC
  • Carcinoma
  • Carcinoma, Hepatocellular

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