Inclusion Criteria:

- Patients must have at least one site of disease which in the opinion of the
investigator is safely accessible by CT guided biopsy or metastasectomy. Safely
accessible metastatic disease will be defined to include those lesions which are
palpable with no overlying viscera and are at least 2cm in size. Given the paucity
of subcutaneous lesions in RCC, lesions which are felt to be safe to biopsy will also
be allowed. These lesions include pleural-based tumors, peripheral liver lesions,
kidney lesions and bone lesions with exophytic soft tissue component. As with
palpable lesions, these other lesions should be at least 2cm in size with no
overlying viscera.

- At least one measurable site of disease, other than the biopsy site, according to
RECIST criterial that has not been previously irradiated. Th the patient has had
previous radiation to the marker lesion(s), there must be evidence of progression
since the radiation

- Metastatic renal carcinoma with histologic confirmation by the treating center of
either primary or a metastatic lesion. Non-clear cell histologies will be allowed

- 18 years of age or older

- Minimum of four weeks since any major surgery, completion of radiation, or completion
of all prior systemic anticancer therapy (adequately recovered from the acute
toxicities of any prior therapy)

- ECOG Performance status of 1 or less

- Adequate bone marrow, liver and renal function as outlined in the protocol

- Fasting serum cholesterol < 300mg/dL OR < 7.75 mmol/L AND fasting triglycerides < 2.5
x ULN

- Life expectancy of greater than 6 months

Exclusion Criteria:

- Prior treatment with any investigation drug within the preceding 4 weeks

- Chronic treatment with systemic steroids or another immunosuppressive agent

- Patients should not receive immunization with attenuated live vaccines within one
week of study entry or during study period

- Uncontrolled brain or leptomeningeal metastases, including patients who continue to
require glucocorticoids for brain or leptomeningeal metastases. Treated brain
metastases will be allowed. Treated brain metastases are defined as having no
evidence of progression or hemorrhage after treatment and no ongoing requirement for
dexamethasone, as ascertained by clinical examination and brain imaging (MRI or CT)
during the screening period. Anticonvulsants (stable dose) are allowed. Treatment
for brain metastases may include whole brain radiotherapy (WBRT), radiosurgery (RS:
Gamma Knife, LINAC or equivalent) or a combination as deemed appropriate by the
treating physician. Patients with CNS metastases treated by neurosurgical resection
performed within 3 months prio to day 1 will be excluded.

- Other malignancies within the past 3 years except for adequately treated carcinoma of
the cervix or basal or squamous cell carcinomas of the skin

- Patients who have any severe and/or uncontrolled medical conditions or other
conditions that could affect their participation in the study

- Uncontrolled diabetes mellitus as defined by a fasting serum > 1.5 x ULN

- A known history of HIV seropositivity.

- Impairment of gastrointestinal function or gastrointestinal disease that may
significantly alter the absorption of everolimus

- Patients with active, bleeding diathesis or on systemic anticoagulation. Aspirin is
permitted.

- Women who are pregnant or breast feeding, or women/men able to conceive and unwilling
to practice an effective method of birth control.

- Patients who have received prior treatment with an mTOR inhibitor.

- Patients with known hypersensitivity to everolimus or other rapamycins or to its
excipients.

- History of noncompliance to medical regimens