Inclusion Criteria

Inclusion Criteria

- Males and females at least 18 years of age

- Histologically- or cytologically- confirmed solid tumor (except melanoma) that is
metastatic or unresectable

- Advanced or metastatic cancer for which no standard therapy exists or that has
progressed despite standard therapy

- Acceptable organ and marrow function during the Screening Period as defined by the
protocol.

- Reliable venous access suitable for weekly study drug infusions

- Willingness and ability to comply with scheduled visits, treatment plans, laboratory
tests, and other study procedures

Exclusion Criteria

- Pregnant or breast-feeding women

- Have had chemotherapy or radiotherapy within 4 weeks prior to entering the study

- Primary brain tumors or active brain metastases

- Treatment with chronic immunosuppressants

- Significant cardiovascular disease, severe acute/chronic medical or psychiatric
condition, or laboratory abnormality that may increase the risk associated with study
participation or study drug administration