Inclusion Criteria:

- ECOG Performance status 0~2(those with performance status 2 must have been stable
with no deterioration over the previous 2 weeks)

- Histologically or cytologically confirmed small cell lung cancer Patient without
chemotherapy and radiotherapy

- Measurable lesion according to RECIST with at least one measurable lesion not
previously irradiated, unless disease progression has been documented at that site

- Life expectancy of at least 3 months

- Provision of written informed consent

Exclusion Criteria:

- As judged by the investigator, any evidence of severe or uncontrolled systemic
disease

- Serum bilirubin greater than 3 times the upper limit of reference range(ULRR)

- Aspartate aminotransferase (AST/SGOT) or alanine aminotransferase (ALT/SGPT)greater
than 2.5 times ULN if no demonstrable liver metastases (or > 5 times in presence of
liver metastases)

- Evidence of any other significant clinical disorder or laboratory finding that makes
it undesirable for the subject to participate in the study

- Pregnancy or breast-feeding women(women of child-bearing potential). Women of
childbearing potential must practice acceptable methods of birth control to prevent
pregnancy

- Evidence of brain metastasis