Trial Information
Exploratory Study of Natural Killer Cells in Human Skin
Then, we will define whether these parameters are qualitatively/ quantitatively modified in
the following skin pathologies: a) atopic dermatitis; b) contact dermatitis; c) psoriasis ;
d) lichen planus ; e) GVH (graft versus host disease) ; (f) melanoma.
Inclusion Criteria:
- Age ≥ 18 years.
- Consent obtained after healthy donor or patient information.
- Patients suffering from one of the following diseases: a) atopic dermatitis ; b)
contact dermatitis; c) psoriasis ; d) lichen planus ; e) GVH ; f) melanoma.
Exclusion Criteria:
- Age below 18,
- pregnant or breastfeeding women,
- persons under guardianship, persons without social security, prisoners, persons
hospitalized without consent on the basis of French laws L. 3212-1 et L. 3213-1.
Patients affected by HIV infection, AIDS, Hepatitis A, B or C infection.
- Neutropenia <1000/mm3.
- Thrombopenia <50 000/mm3.
Type of Study:
Interventional
Study Design:
Intervention Model: Parallel Assignment, Masking: Open Label
Outcome Measure:
In a first time, we will characterize the tissue distribution, the phenotype and the effector functions of NK cells present in the human healthy skin.
Outcome Time Frame:
12 months
Safety Issue:
No
Principal Investigator
Caroline Gaudy-Marqueste, MD
Investigator Role:
Principal Investigator
Investigator Affiliation:
Assistance Publique des Hopitaux de Marseille
Authority:
France: Ministry of Health
Study ID:
2008-A00064-51
NCT ID:
NCT00824889
Start Date:
Completion Date:
Related Keywords:
- Atopic Dermatitis
- Contact Dermatitis
- Psoriasis
- Lichen Planus
- Graft Versus Host Disease
- Melanoma
- Dermatitis
- Dermatitis, Atopic
- Dermatitis, Contact
- Graft vs Host Disease
- Lichen Planus
- Melanoma
- Psoriasis