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Exploratory Study of Natural Killer Cells in Human Skin


N/A
18 Years
N/A
Open (Enrolling)
Both
Atopic Dermatitis, Contact Dermatitis, Psoriasis, Lichen Planus, Graft Versus Host Disease, Melanoma

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Trial Information

Exploratory Study of Natural Killer Cells in Human Skin


Then, we will define whether these parameters are qualitatively/ quantitatively modified in
the following skin pathologies: a) atopic dermatitis; b) contact dermatitis; c) psoriasis ;
d) lichen planus ; e) GVH (graft versus host disease) ; (f) melanoma.


Inclusion Criteria:



- Age ≥ 18 years.

- Consent obtained after healthy donor or patient information.

- Patients suffering from one of the following diseases: a) atopic dermatitis ; b)
contact dermatitis; c) psoriasis ; d) lichen planus ; e) GVH ; f) melanoma.

Exclusion Criteria:

- Age below 18,

- pregnant or breastfeeding women,

- persons under guardianship, persons without social security, prisoners, persons
hospitalized without consent on the basis of French laws L. 3212-1 et L. 3213-1.
Patients affected by HIV infection, AIDS, Hepatitis A, B or C infection.

- Neutropenia <1000/mm3.

- Thrombopenia <50 000/mm3.

Type of Study:

Interventional

Study Design:

Intervention Model: Parallel Assignment, Masking: Open Label

Outcome Measure:

In a first time, we will characterize the tissue distribution, the phenotype and the effector functions of NK cells present in the human healthy skin.

Outcome Time Frame:

12 months

Safety Issue:

No

Principal Investigator

Caroline Gaudy-Marqueste, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Assistance Publique des Hopitaux de Marseille

Authority:

France: Ministry of Health

Study ID:

2008-A00064-51

NCT ID:

NCT00824889

Start Date:

Completion Date:

Related Keywords:

  • Atopic Dermatitis
  • Contact Dermatitis
  • Psoriasis
  • Lichen Planus
  • Graft Versus Host Disease
  • Melanoma
  • Dermatitis
  • Dermatitis, Atopic
  • Dermatitis, Contact
  • Graft vs Host Disease
  • Lichen Planus
  • Melanoma
  • Psoriasis

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