Treatment Intensification With R-ICE and High-Dose Cyclophosphamide for Diffuse Large B-Cell Non-Hodgkin's Lymphoma Based on Early [18F] FDG-PET Scanning
Patients will receive 3 cycles of chemotherapy prior to mid-treatment PET-CT.
Rituximab-CHOP, or an equivalent regimen must be used. During the third cycle of
Rituximab-CHOP chemotherapy, a PET-CT scan will be performed. The PET scan will be
designated as negative or positive. Based on the results, patients will either complete
standard dose therapy or receive two cycles of R-ICE followed by high dose cyclophosphamide
A repeat PET-CT is required between 4 to 6 weeks following treatment completion. Patients
will be followed-up every 4 months for 2 years, then every 6 months for one year, then
annually until 5 years.
Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Estimate survival in patient receiving early treatment intensification based on a positive mid-treatment PET scan compared to the historical event-free survival of mid-treatment PET positive patients not given early treatment intensification.
Lode Swinnen, MD
Johns Hopkins University
United States: Institutional Review Board
|The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins||Baltimore, Maryland 21231|