Development of a Blood Test of Anti-IMP3 Autoantibody for the Detection of Renal Cell Carcinoma With Metastasis and Metastatic Potential
- To develop an anti-IMP3 autoantibody blood test to identify the status of current and
potential metastasis in patients with localized or metastatic renal cell carcinoma.
OUTLINE: Serum samples obtained prior to surgery are analyzed for anti-IMP3 autoantibody by
ELISA. Tissue samples obtained at the time of surgery are examined for IMP3 gene
overexpression by IHC. The results of the ELISA serum assay are then compared with the
results of the IHC tissue analysis to evaluate the sensitivity and specificity of the assay.
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Presence of metastatic renal cell carcinoma
After blood draw prior to surgery or other treatment
Huiqing Wu, MD
City of Hope Medical Center
United States: Institutional Review Board
|City of Hope Medical Center||Duarte, California 91010|