Inclusion Criteria:

- histologically confirmed HNSCC

- adequate primary site: oral cavity, oropharynx, hypopharynx, nasal cavity, paranasal
sinus, other head and neck site (except nasopharynx)

- at least one measurable lesion

- no previous palliative chemotherapy (adjuvant/neoadjuvant chemotherapy and/or
radiotherapy longer than 6 months ago is permitted)

- 18 years or older

- ECOG 0 or 1

- adequate laboratory result

- written, informed consent

Exclusion Criteria:

- pregnant or lactating women (negative pregnancy test within 7 days is required for
women with potential of child-bearing)

- experimental drug clinical trial within 30 days

- other malignancy (exemption: treated basal cell carcinoma of skin, CIS, cured cancer
with disease-free interval with more than 5 years)

- patient with organ transplantation

- grade 2 or more peripheral neuropathy

- grade 2 or more hearing loss

- severe, medical condition