Inclusion Criteria:

- Patients must have cytologically or histologically proven advanced solid tumors for
which there is no known standard therapy available or are not eligible for standard
therapy because of their performance status, or have progressed after standard
therapy.

- Patients must have measurable or evaluable disease

- Patients must be 18 years of age or older

- Patients must have a Zubrod performance status of 0-2

- Patients must have an estimated survival of at least 3 months

- Any prior chemotherapy must have been completed at least 3 weeks prior to start of
this protocol and all side effects (except alopecia) resolved to grade 1 or less.
Any prior radiation must have been completed at least 2 weeks prior to start of
therapy. Patients must have completed prior trastuzumab (Herceptin) at least 4 weeks
prior to start of protocol therapy

- Patients must have adequate renal function

- Patients must have adequate liver function

- Patients must have a pretreatment granulocyte count of >1500/mm3 and platelet count
of >100 000/mm3.

- Patients must have a cardiac ejection fraction within the institutional range of
normal as measured by 2-D echocardiogram or MUGA scan.

- All patients must give informed consent

- Patients must be able to take and retain oral medication

- Patients of reproductive potential must agree to use an effective contraceptive
method while on treatment as the effects of these drugs on the unborn fetus are
unknown.

Exclusion Criteria:

- Patients may not have previously received lapatinib, ixabepilone or any other
EGFR-TKI targeted agent. Prior trastuzumab (Herceptin) is allowed.

- Patients may not pregnant or breastfeeding as the effects of these drugs on the
unborn fetus are unknown.

- Patients with symptomatic brain metastasis or still requiring steroids and
anticonvulsants may not participate. Patients with asymptomatic treated brain
metastasis (surgical resection or radiotherapy) may be included if they are
neurologically stable and have been off steroids for at least 2 weeks.

- Patients with pre-existing neuropathy > grade 2 may not participate.

- Patients with uncontrolled intercurrent illness including, but not limited to,
ongoing or active infection, symptomatic congestive heart failure, unstable angina
pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would
limit compliance with study requirements, will be excluded.

- History of other diseases, metabolic dysfunction, physical examination finding or
clinical laboratory finding giving reasonable suspicion of a disease or condition
that contraindicates the use of an investigational drug or that might affect the
interpretation of the results of the study or render the patient at high risk from
treatment complications.

- Gastrointestinal tract disease resulting in an inability to take oral medication or a
requirement for IV alimentation, or prior surgical procedures affecting absorption.

- HIV-positive patients receiving combination antiretroviral therapy are excluded from
the study because of possible pharmacokinetic interactions with lapatinib.
Appropriate studies will be undertaken in patients receiving combination
antiretroviral therapy when indicated.

- Patients requiring oral anticoagulants are eligible provided there is appropriate
close INR monitoring in place.

- Prior radiation must not have included more than 30% of bone marrow containing areas

- Any prior, severe history of hypersensitivity reaction to a drug formulated in
CremaphorEL

- Adherence to the requirements for concomitant medications classified as CYP3A4
inducers or inhibitors, or gastric pH modifiers