Inclusion Criteria:

- Confirmed diagnosis of advanced non-hematologic malignancy. Dose expansion cohort
restricted to subjects with advanced or metastatic gastroesophageal cancer, squamous
cell cancers of the head and neck, and castration resistant prostate cancer

- ECOG status 0-1

Exclusion Criteria:

- WOCBP unwilling/unable to use acceptable contraception methods, and women pregnant or
breast feeding

- Symptomatic brain metastasis

- Uncontrolled or significant cardiovascular disease

- History of thromboembolic events or bleeding diathesis in past 6 months

- Conditions requiring prophylactic anticoagulation or chronic anti-platelet therapy

- Serious non-healing wounds, ulcers or bone fractures in past 3 months

- Hemorrhage or bleeding event >= CTCAE grade 3 in past 4 weeks

- Proteinuria >= 2+ on dipstick or >= 1gm/24 hours

- Concurrent chemotherapy, hormonal therapy, immunotherapy, radiation therapy or
therapy with any other investigational product

- Concurrent herbal, alternative, food supplements, or strong CYP 3A4 inhibitors or
inducers