Inclusion Criteria:

1. patients currrently participating in Novartis study CAMN107A2109

2. imatinib - resistant or intolerant - Philadelphia chromosome-positive CML in chronic
(CML-CP)accelerated phase (CML-AP) or in blast crisis (CML-BC)

3. males or females ≥18 years of age

4. WHO Performance Status of ≤ 2

5. patients must have the following laboratory values: ALT and AST ≤ 2.5 x ULN or ≤ 5.0
x ULN if considered due to tumor

Exclusion Criteria:

1. Impaired cardiac function; use of therapeutic coumarin derivatives

2. patients who have undergone a major surgery and have not recovered from side effects
of such therapy within 15 days

3. patients who are pregnant or breast feeding, or adults of reproductive potential not
employing an effective method of birth control

4. patients who have received chemotherapy ≤ 1 week or who are within 5 half-lives of
their last dose of chemotherapy

5. ,.patients who have received imatinib or dasatinib at least 3 days prior to beginning
of study drug or who have not recovered from side effects of such therapy