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A Randomized Phase III Trial of Weekly Paclitaxel Compared to Weekly Nanoparticle Albumin Bound Nab-Paclitaxel or Ixabepilone With or Without Bevacizumab as First-line Therapy for Locally Recurrent or Metastatic Breast Cancer


Phase 3
18 Years
N/A
Open (Enrolling)
Both
Male Breast Cancer, Recurrent Breast Cancer, Stage IIIC Breast Cancer, Stage IV Breast Cancer

Thank you

Trial Information

A Randomized Phase III Trial of Weekly Paclitaxel Compared to Weekly Nanoparticle Albumin Bound Nab-Paclitaxel or Ixabepilone With or Without Bevacizumab as First-line Therapy for Locally Recurrent or Metastatic Breast Cancer


PRIMARY OBJECTIVES:

I. To compare the progression-free survival of patients with stage IIIC or IV breast cancer
treated with paclitaxel albumin-stabilized nanoparticle formulation (nab-paclitaxel) versus
ixabepilone versus paclitaxel with or without bevacizumab.

SECONDARY OBJECTIVES:

I. To compare the objective response rate, duration of response, and time to treatment
failure in patients receiving nab-paclitaxel versus paclitaxel, and to separately compare
these endpoints in patients receiving ixabepilone versus paclitaxel.

II. To compare the 12-month rate of progression in patients treated with these regimens.

III. To compare treatment-related toxicities in patients receiving these regimens, according
to the rates of grade 3/4 sensory neuropathy and the rates of peripheral neuropathy assessed
by the FACT/GOG neurotoxicity subscale.

IV. To compare overall survival of patients receiving these regimens. V. To prospectively
collect data on sociodemographics, non-cancer morbidities, and receipt of post-trial therapy
to evaluate the role of potential disparities on survival from cancer.

VI. To evaluate the relationships between SPARC overexpression and changes in blood levels
of caveolin-1 (Cav-1) to PFS and secondary endpoints of response during treatment in these
patients.

V. To evaluate the relationships between changes in blood levels of circulating tumor cells
(CTCs) and circulating endothelial cells (CECs) to PFS and secondary endpoints of response
during treatment in these patients.

VII. To evaluate the association of expression levels of the microtubule associated proteins
tau and beta-tubulin isotype composition with PFS and secondary endpoints of response during
treatment.

VIII. To investigate a potential CYP2C8*2/*3 by paclitaxel interaction with respect to
progression-free survival (PFS).

IX. To determine if CYP2C8*2 and CPY2C8*3 are associated with paclitaxel-induced peripheral
neuropathy.

X. To perform exploratory analysis of CYP3A4, CYP3A5, ABCB1 and ABCC2 polymorphisms with
response and toxicity profiles.

XI. To prospectively collect data on sociodemographics, non-cancer morbidities, and receipt
of post-trial therapy to evaluate the role of potential disparities on survival from cancer.

XII. To evaluate the relationship between physical activity behaviors at the time of study
enrollment and progression-free and overall survival.

XIII. To identify baseline factors that predict the risk of grade 3, 4, or 5 toxicity in
patients receiving treatment with weekly paclitaxel, nab-paclitaxel, or ixabepilone combined
with or without bevacizumab.

XIV. To perform an exploratory analysis of whether other factors included in patient
assessments (either individually or in combination) predict the risk of grade 3, 4, or 5
toxicity in patients receiving weekly paclitaxel, nab-paclitaxel, or ixabepilone combined
with or without bevacizumab, with a specific focus on the relationship between pre-existing
hypertension or neuropathy. (Exploratory) XV. To compare the associations of baseline
factors to grade 3, 4, or 5 toxicity in patients receiving weekly paclitaxel,
nab-paclitaxel, or ixabepilone combined with or without bevacizumab.

XVI. To explore whether longitudinal changes in factors are in association with the
occurrence of grade 3, 4, or 5 toxicities in patients with weekly paclitaxel, nabpaclitaxel,
or ixabepilone combined with or without bevacizumab. (Exploratory) XVII. To explore the
association between grade 2-4 neuropathy and longitudinal changes in the following
functional status measures: a) OARS MFAQ (IADL); b) MOS Physical Functioning; c) Karnofsky
Performance Status Rated Healthcare Professional; d) Timed "Up and Go"; e) OARS Physical
Health Section.

(Exploratory)

OUTLINE: This is a multicenter study. Patients are stratified according to taxane as
adjuvant therapy (yes or no), estrogen receptor (ER) or progesterone receptor (PgR) status
(ER-positive or PgR-positive vs both ER-negative and PgR-negative), physician's decision to
use bevacizumab (yes vs no). Patients are randomized to 1 of 3 treatment arms.

ARM I: (weekly paclitaxel) Patients receive paclitaxel IV over 1 hour on days 1, 8, and 15.
Patients may also receive bevacizumab IV over 30-90 minutes on days 1 and 15.

ARM II: (weekly paclitaxel albumin-stabilized nanoparticle formulation [nab-paclitaxel])
Patients receive nab-paclitaxel IV over 30 minutes on days 1, 8, and 15. Patients may also
receive bevacizumab as in arm I.

ARM III: (weekly ixabepilone) Patients receive ixabepilone IV over 60 minutes on days 1, 8,
and 15. Patients may also receive bevacizumab as in arm I.

In all arms, treatment repeats every 28 days in the absence of disease progression or
unacceptable toxicity. Patients complete questionnaires about peripheral neuropathy at
baseline and before each course of therapy. They also complete questionnaires about
sociodemographics, non-cancer comorbidities, social support, physical activity, and
post-trial therapy at baseline and periodically thereafter. Blood samples may be collected
at baseline and periodically during study for correlative studies. Tumor tissue samples from
diagnosis may be also collected.

After completion of study therapy, patients are followed every 6 months for 2 years and then
annually for up to 3 years.


Inclusion Criteria:



- Histologically confirmed invasive breast cancer

- Stage IIIC or IV (locally recurrent or metastatic) disease not amenable to local
therapy

- Measurable disease (target lesions), defined as ≥ 1 lesion that can be accurately
measured in ≥ 1 dimension (longest diameter to be recorded) as ≥ 2.0 cm with
conventional techniques or as ≥ 1 cm with spiral CT scan

- No non-measurable lesions, including any of the following:

- Ascites

- Pleural/pericardial effusion

- Inflammatory breast disease

- Lymphangitis cutis/pulmonitis

- Bone lesions

- Leptomeningeal disease

- Cystic lesions

- Abdominal masses not confirmed and followed by imaging techniques

- HER2/neu status must be known

- HER2-positive disease allowed provided patient received prior trastuzumab
(Herceptin®) or lapatinib (documentation of progression on HER2-directed therapy
is not required)

- No progressing or untreated CNS metastases or leptomeningeal disease

- History of resected brain metastases with stable MRI scans for 3 months,
including within the past 4 weeks allowed

- History of gamma-knife radiosurgery or whole-brain radiation with stable MRI
scans for 3 months, including within the past 4 weeks allowed

- Hormone receptor status must be known

- Estrogen receptor (ER)- and progesterone receptor (PgR)-positive if ≥ 1% cells
are positive

- Menopausal status not specified

- ECOG (Zubrod) performance status 0-1

- Life expectancy ≥ 12 weeks

- Granulocytes ≥ 1,500/μL

- Platelet count ≥ 100,000/μL

- Creatinine ≤ 2.0 mg/dL

- Bilirubin < 1.5 mg/dL (unless due to Gilbert's syndrome)

- AST and ALT ≤ 2.5 times upper limit of normal

- Urine protein ≤ 1+ OR urine protein: creatinine ratio < 1

- Patients with proteinuria ≥ 2+ at baseline must undergo a 24-hoururine
collection that demonstrates < 1 g of protein/24 hr or UPC ratio ≤ 1

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception

- History of seizures allowed if well controlled with standard medication

- No history of hypersensitivity to paclitaxel or Cremophor® EL CTCAE grade ≥ 3

- No other active malignancy except nonmelanoma skin cancer (patients are not
considered to have a "currently active" malignancy if they have completed therapy and
are considered by their physician to have less than 30% risk of relapse)

- No history of abdominal fistula or intra-abdominal abscess within 6 months prior to
study registration

- No history of gastrointestinal (GI) perforation within the past 12 months

- No history of significant bleeding episodes (e.g., hemoptysis, upper or lower GI
bleeding) within the past 6 months

- No history of stroke or transient ischemic attack within the past 6 months

- No history of clinically significant cardiovascular disease including any of the
following:

- Uncontrolled hypertension, defined as systolic blood pressure (BP) > 150 mm Hg
and/or diastolic BP > 90 mm Hg on antihypertensive medications

- Prior history of hypersensitivity or hypertensive encephalopathy

- History of myocardial infarction or unstable angina within past 6 months

- NYHA congestive heart failure class II-IV

- Symptomatic peripheral vascular disease

- Significant vascular disease (e.g., aortic aneurysm or aortic dissection) or
arterial thrombotic events

- No serious, non-healing wound, ulcer, or bone fracture

- No significant traumatic injury in the past 28 days

- No peripheral neuropathy ≥ grade 2

- Concurrent full-dose anticoagulants allowed but patient must be on a stable dose of
warfarin or low molecular weight heparin

- Anti-platelet therapy or on daily prophylactic-dose aspirin allowed

- Stable doses of anticoagulation for atrial fibrillation allowed

- No prior chemotherapy regimen for metastatic disease

- Adjuvant or neoadjuvant taxane allowed provided interval between completion of
adjuvant therapy and disease recurrence is ≥ 12 months

- At least 2 weeks since prior radiotherapy

- At least 28 days since prior major surgical procedure or open biopsy and fully
recovered

- There are no restrictions on core biopsies, placement of a vascular access
device, or other minor procedures prior to registration.

- At least 7 days since prior hormonal therapy

- Any number of prior hormonal therapies allowed

- Prior trastuzumab or lapatinib ditosylate for HER2-overexpressing tumors allowed

- Prior bevacizumab allowed

- Prior and concurrent bisphosphonate treatment allowed

- No concurrent major surgical procedure

- No concurrent palliative radiotherapy

- No concurrent aprepitant

- No concurrent pegfilgrastim

- No other concurrent chemotherapy or anticancer hormone therapy

Type of Study:

Interventional

Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Progression-free survival (PFS) of each experimental arm to the PFS of the control arm

Outcome Description:

The primary analysis will use the stratified log-rank tests to identify differences in PFS for each experimental arm as compared to control arm (based upon the trial's stratification factors: prior adjuvant taxanes, hormone receptor status, and concomitant bevacizumab). Any efficacy claim will be based solely on this primary statistical analysis. As a secondary analysis we will use the stratified log-rank test to test for a difference between arms after adjusting for disease-free interval and visceral metastases versus bone/soft tissue metastases.

Outcome Time Frame:

Time from randomization to progression or death due to any cause, whichever occurs first, assessed up to 5 years

Safety Issue:

No

Principal Investigator

Hope Rugo

Investigator Role:

Principal Investigator

Investigator Affiliation:

Cancer and Leukemia Group B

Authority:

United States: Food and Drug Administration

Study ID:

NCI-2009-00476

NCT ID:

NCT00785291

Start Date:

October 2008

Completion Date:

Related Keywords:

  • Male Breast Cancer
  • Recurrent Breast Cancer
  • Stage IIIC Breast Cancer
  • Stage IV Breast Cancer
  • Breast Neoplasms
  • Breast Neoplasms, Male

Name

Location

Albert Einstein College of MedicineBronx, New York  10461
Memorial Sloan Kettering Cancer CenterNew York, New York  10021
Roswell Park Cancer InstituteBuffalo, New York  14263
Mayo ClinicRochester, Minnesota  55905
University of Iowa Hospitals and ClinicsIowa City, Iowa  52242
Washington University School of MedicineSaint Louis, Missouri  63110
Abington Memorial HospitalAbington, Pennsylvania  19001
Hurley Medical CenterFlint, Michigan  48503
Sinai Hospital of BaltimoreBaltimore, Maryland  21225
Beth Israel Deaconess Medical CenterBoston, Massachusetts  02215
Boulder Community HospitalBoulder, Colorado  80301-9019
Porter Adventist HospitalDenver, Colorado  80210
Rose Medical CenterDenver, Colorado  80220
Swedish Medical CenterEnglewood, Colorado  80110
Sky Ridge Medical CenterLone Tree, Colorado  80124
North Suburban Medical CenterThornton, Colorado  80229
Bronson Methodist HospitalKalamazoo, Michigan  49007
West Michigan Cancer CenterKalamazoo, Michigan  49007-3731
Borgess Medical CenterKalamazooaa, Michigan  49001
Fairview Ridges HospitalBurnsville, Minnesota  55337
Hutchinson Area Health CareHutchinson, Minnesota  55350
Meeker County Memorial HospitalLichfield, Minnesota  55355
United HospitalSt. Paul, Minnesota  55102
Ridgeview Medical CenterWaconia, Minnesota  55387
Geisinger Medical CenterDanville, Pennsylvania  17822-0001
Massachusetts General Hospital Cancer CenterBoston, Massachusetts  02114
CentraCare ClinicSaint Cloud, Minnesota  56303
Rapid City Regional HospitalRapid City, South Dakota  57709
Morristown Memorial HospitalMorristown, New Jersey  07962-1956
Marshfield ClinicMarshfield, Wisconsin  54449
Sutter Health Western Division Cancer Research GroupGreenbrae, California  94904
Loma Linda University Medical CenterLoma Linda, California  92354
Methodist Medical Center of IllinoisPeoria, Illinois  61636
Memorial Hospital of South BendSouth Bend, Indiana  46601
Akron General Medical CenterAkron, Ohio  44302
Lehigh Valley HospitalAllentown, Pennsylvania  18103
Martha Jefferson HospitalCharlottesville, Virginia  22901
Waukesha Memorial HospitalWaukesha, Wisconsin  53188
Dana-Farber Cancer InstituteBoston, Massachusetts  02115
Virginia Piper Cancer InstituteMinneapolis, Minnesota  55407
North Shore University HospitalManhasset, New York  11030
Boston Medical CenterBoston, Massachusetts  02118
Illinois Masonic Medical CenterChicago, Illinois  60657
Eastern Maine Medical CenterBangor, Maine  04401
Staten Island University HospitalStaten Island, New York  10305
William Beaumont HospitalRoyal Oak, Michigan  48073
Kaiser Permanente Medical Center - Santa ClaraSanta Clara, California  95051-5386
Via Christi Regional Medical CenterWichita, Kansas  67214
Ochsner Clinic FoundationNew Orleans, Louisiana  70121
University of Oklahoma Health Sciences CenterOklahoma City, Oklahoma  73104
Iowa Methodist Medical CenterDes Moines, Iowa  50309
Iowa Lutheran HospitalDes Moines, Iowa  50316-2301
New Hanover Regional Medical CenterWilmington, North Carolina  28402-9025
Southern California Permanente Medical GroupDowney, California  90242
Great Falls ClinicGreat Falls, Montana  59405
Thompson Cancer Survival CenterKnoxville, Tennessee  37916
Overlook HospitalSummit, New Jersey  07902-0220
MetroHealth Medical CenterCleveland, Ohio  44109
Long Island Jewish Medical CenterNew Hyde Park, New York  11040
Montefiore Medical CenterBronx, New York  10467-2490
Chester County HospitalWest Chester, Pennsylvania  19380
Sibley Memorial HospitalWashington, District of Columbia  20016
Somerset Medical CenterSomerville, New Jersey  08876
North Colorado Medical CenterGreeley, Colorado  80631
McKee Medical CenterLoveland, Colorado  80539
Cancer Center of Kansas - ChanuteChanute, Kansas  66720
Cancer Center of Kansas - Dodge CityDodge City, Kansas  67801
Cancer Center of Kansas - NewtonNewton, Kansas  67114
Cancer Center of Kansas - SalinaSalina, Kansas  67042
Cancer Center of Kansas - WellingtonWellington, Kansas  67152
Associates in Womens HealthWichita, Kansas  67203
Cancer Center of Kansas - WinfieldWinfield, Kansas  67156
Munson Medical CenterTraverse City, Michigan  49684
Northern Rockies Radiation Oncology CenterBillings, Montana  59101
Bozeman Deaconess HospitalBozeman, Montana  59715
Big Sky OncologyGreat Falls, Montana  59405
Kalispell Medical OncologyKalispell, Montana  59901
Kalispell Regional Medical CenterKalispell, Montana  59901
Adena Regional Medical CenterChillicothe, Ohio  54601
Grady Memorial HospitalDelaware, Ohio  43015
Fairfield Medical CenterLancaster, Ohio  43130
Medical X-Ray CenterSioux Falls, South Dakota  57105
Welch Cancer CenterSheridan, Wyoming  82801
Brigham and Women's HospitalBoston, Massachusetts  02115
Methodist Estabrook Cancer CenterOmaha, Nebraska  68114-4199
Cancer Centers of the CarolinasGreenville, South Carolina  29605
City of Hope Medical CenterDuarte, California  91010
Mercy Health SystemJanesville, Wisconsin  53545
Paoli Memorial HospitalPaoli, Pennsylvania  19301-1792
Elkhart General HospitalElkhart, Indiana  46515
South Bend ClinicSouth Bend, Indiana  46617
Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical CenterColumbus, Ohio  43210-1240
Front Range Cancer SpecialistsFort Collins, Colorado  80528
University Medical Center of Southern NevadaLas Vegas, Nevada  89102
Jennersville Regional HospitalWest Grove, Pennsylvania  19390-9499
Alta Bates Summit Medical Center - Summit CampusOakland, California  94609
Sutter Solano Medical CenterVallejo, California  94589
Poudre Valley HospitalFort Collins, Colorado  80524
Beebe Medical CenterLewes, Delaware  19958
Saint Joseph's Hospital of AtlantaAtlanta, Georgia  30342-1701
Piedmont HospitalAtlanta, Georgia  30309
Gwinnett Medical CenterLawrenceville, Georgia  30045
Southern Regional Medical CenterRiverdale, Georgia  30274-2600
Memorial HospitalCarthage, Illinois  62321
Swedish Covenant HospitalChicago, Illinois  60625
Galesburg Cottage HospitalGalesburg, Illinois  61401
Galesburg ClinicGalesburg, Illinois  61401
Mason District HospitalHavana, Illinois  62644
McDonough District HospitalMacomb, Illinois  61455
BroMenn Regional Medical CenterNormal, Illinois  61761
Proctor HospitalPeoria, Illinois  61614
Perry Memorial HospitalPrinceton, Illinois  61356
Valley Cancer CenterSpring Valley, Illinois  61362
Genesis Medical Center - West CampusDavenport, Iowa  52804
Mecosta County Medical CenterBig Rapids, Michigan  49307
Community Cancer Center of MonroeMonroe, Michigan  48162
Creighton University Medical CenterOmaha, Nebraska  68131-2197
Iredell Memorial HospitalStatesville, North Carolina  28677
Bismarck Cancer CenterBismarck, North Dakota  58501
Grandview HospitalDayton, Ohio  45405
Lima Memorial HospitalLima, Ohio  45804
Mercy Medical CenterSpringfield, Ohio  45504
Mercy Hospital of TiffinTiffin, Ohio  44883
Fulton County Health CenterWauseon, Ohio  43567
Legacy Mount Hood Medical CenterGresham, Oregon  97030
Providence Milwaukie HospitalMilwaukie, Oregon  97222
Legacy Meridian Park HospitalTualatin, Oregon  97062
Bryn Mawr HospitalBryn Mawr, Pennsylvania  19010
Mountainview MedicalBerlin, Vermont  05602
Danville Regional Medical CenterDanville, Virginia  24541
Exempla Lutheran Medical CenterWheat Ridge, Colorado  80033
Eureka HospitalEureka, Illinois  61530
Mercy HospitalCoon Rapids, Minnesota  55433
Allenmore HospitalTacoma, Washington  98411-0414
Graham Hospital AssociationCanton, Illinois  61520
Holy Family Medical CenterDes Plaines, Illinois  60016
Saint Joseph Medical CenterJoliet, Illinois  60435
Pekin HospitalPekin, Illinois  61554
Medical Oncology and Hematology AssociatesDes Moines, Iowa  50309
Bixby Medical CenterAdrian, Michigan  49221
Saint Joseph Mercy HospitalAnn Arbor, Michigan  48106
Fairview-Southdale HospitalEdina, Minnesota  55435
Abbott-Northwestern HospitalMinneapolis, Minnesota  55407
Regions HospitalSaint Paul, Minnesota  55101
Saint Francis Regional Medical CenterShakopee, Minnesota  55379
Rice Memorial HospitalWillmar, Minnesota  56201
Altru Cancer CenterGrand Forks, North Dakota  58206
Saint Luke's HospitalMaumee, Ohio  43537
Geisinger Medical GroupState College, Pennsylvania  16801
Highland General HospitalOakland, California  94602
Swedish American HospitalRockford, Illinois  61104
Center for Cancer Care and ResearchSt. Louis, Missouri  63141
Randolph HospitalAsheboro, North Carolina  27203
Miami Valley HospitalDayton, Ohio  45409
Spartanburg Regional Medical CenterSpartanburg, South Carolina  29303
Cancer Center of Kansas - Fort ScottFort Scott, Kansas  66701
Cancer Center of Kansas-IndependenceIndependence, Kansas  67301
Lawrence Memorial HospitalLawrence, Kansas  66044
Menorah Medical CenterOverland Park, Kansas  66209
Shawnee Mission Medical CenterShawnee Mission, Kansas  66204
North Kansas City HospitalKansas City, Missouri  64116
Research Medical CenterKansas City, Missouri  64132
Saint Luke's East - Lee's SummitLee's Summit, Missouri  64086
Liberty HospitalLiberty, Missouri  64068
Heartland Regional Medical CenterSaint Joseph, Missouri  64506
Bozeman Deaconess Cancer CenterBozeman, Montana  59715
Northern Montana HospitalHavre, Montana  59501
Mary Rutan HospitalBellefontaine, Ohio  43311
Wayne HospitalGreenville, Ohio  45331
Knox Community HospitalMount Vernon, Ohio  43050
Fisher-Titus Medical CenterNorwalk, Ohio  44857
Clinton Memorial HospitalWilmington, Ohio  45177
Adventist Medical CenterPortland, Oregon  97216
Providence Centralia HospitalCentralia, Washington  98531-9027
Marshfield Clinic Cancer Care at Regional Cancer CenterEau Claire, Wisconsin  54701
Saint Joseph's HospitalMarshfield, Wisconsin  54449
Marshfield Clinic - Weston CenterWeston, Wisconsin  54476
Marshfield Clinic - Wisconsin Rapids CenterWisconsin Rapids, Wisconsin  54494
Rocky Mountain OncologyCasper, Wyoming  82609
Longmont United HospitalLongmont, Colorado  80501
Memorial Hospital of Rhode IslandPawtucket, Rhode Island  02860
Singing River HospitalPascagoula, Mississippi  39581
Greene Memorial HospitalXenia, Ohio  45385
Greater Baltimore Medical CenterBaltimore, Maryland  21204
Rutherford HospitalRutherfordton, North Carolina  28139
Three Rivers Community HospitalGrants Pass, Oregon  97527
Providence Medford Medical CenterMedford, Oregon  97504
AnMed Health Cancer CenterAnderson, South Carolina  29621
Harold Alfond Center for Cancer CareAugusta, Maine  04330
Union Hospital of Cecil CountyElkton MD, Maryland  21921
Cancer Centers of the Carolinas - Grove CommonsGreenville, South Carolina  29605
Cancer Centers of the Carolinas - SenecaSeneca, South Carolina  29672
Cancer Centers of the Carolinas - SpartanburgSpartanburg, South Carolina  29307
Presbyterian HospitalCharlotte, North Carolina  28233-3549
Mayo Clinic in ArizonaScottsdale, Arizona  85259-5404
Mayo Clinic in FloridaJacksonville, Florida  32224
Washington Hospital CenterWashington, District of Columbia  20010
Sherman HospitalElgin, Illinois  60120-2198
Memorial Medical CenterSpringfield, Illinois  62781
Phelps County Regional Medical CenterRolla, Missouri  65401
Southeastern Medical Oncology CenterGoldsboro, North Carolina  27534
Doylestown HospitalDoylestown, Pennsylvania  18901
McLeod Regional Medical CenterFlorence, South Carolina  29501
Metro Health HospitalGrand Rapids, Michigan  49506
Guardian Oncology and Center for WellnessMissoula, Montana  59804
Queen's Medical CenterHonolulu, Hawaii  96813
University of VirginiaCharlottesville, Virginia  22908
University of PittsburghPittsburgh, Pennsylvania  15261
Newton-Wellesley HospitalNewton, Massachusetts  02462
University of North CarolinaChapel Hill, North Carolina  27599
Duke University Medical CenterDurham, North Carolina  27710
Meharry Medical CollegeNashville, Tennessee  37208-3599
Lynchburg Hematology-Oncology ClinicLynchburg, Virginia  24501
Cancer Care AssociatesTulsa, Oklahoma  74136
East Bay Radiation Oncology CenterCastro Valley, California  94546
Contra Costa Regional Medical CenterMartinez, California  94553-3156
Larry G Strieff MD Medical CorporationOakland, California  94609
Kapiolani Medical Center at Pali MomiAiea, Hawaii  96701
Kapiolani Medical Center for Women and ChildrenHonolulu, Hawaii  96826
Maui Memorial Medical CenterWailuku, Hawaii  96793
Elmhurst Memorial HospitalElmhurst, Illinois  60126
Hennepin County Medical CenterMinneapolis, Minnesota  
Saint Louis University HospitalSt. Louis, Missouri  63110-0250
Holy Cross HospitalFort Lauderdale, Florida  33308
El Camino HospitalMountain View, California  94040
University of California at San DiegoLa Jolla, California  92093
Yale UniversityNew Haven, Connecticut  06520
Kaiser Permanente Medical CenterVallejo, California  94589
New Hampshire Oncology-Hematology PAHooksett, New Hampshire  03106
Albert Einstein Medical CenterPhiladelphia, Pennsylvania  19141
Straub Clinic and HospitalHonolulu, Hawaii  96813
Riverside Methodist HospitalColumbus, Ohio  43214
Licking Memorial HospitalNewark, Ohio  43055-2899
Providence Portland Medical CenterPortland, Oregon  97213-3635
California Pacific Medical CenterSan Francisco, California  94115
Dartmouth Hitchcock Medical CenterLebanon, New Hampshire  03756
Mid Dakota ClinicBismarck, North Dakota  58501
Columbus CCOPColumbus, Ohio  43206
Weiss Memorial HospitalChicago,, Illinois  60640
University Of VermontBurlington,, Vermont  05403
Presbyterian - Saint Lukes Medical Center - Health OneDenver, Colorado  80218
Kaiser PermanenteSacramento, California  
University of Texas Southwestern Medical CenterDallas, Texas  
Wichita CCOPWichita, Kansas  67214-3882
Montana Cancer Consortium CCOPBillings, Montana  59101
Alegent Health Immanuel Medical CenterOmaha, Nebraska  68122
Alegent Health Bergan Mercy Medical CenterOmaha, Nebraska  68124
Flower HospitalSylvania, Ohio  43560-2197
Mount Sinai Hospital Medical CenterChicago, Illinois  60608
Addison Gilbert HospitalGloucester, Massachusetts  01930
Southeastern Regional Medical CenterLumberton, North Carolina  28359
Granville Medical CenterOxford, North Carolina  27565
Person Memorial HospitalRoxboro, North Carolina  27573
Columbia Saint Mary's Hospital - OzaukeeMequon, Wisconsin  53097
Metro-Minnesota CCOPSt. Louis Park, Minnesota  
Tufts Medical CenterBoston, Massachusetts  02111
Cancer Centers of the Carolinas - EasleyEasley, South Carolina  29640
Lakeview HospitalStillwater, Minnesota  55082
Thomas Jefferson University HospitalPhiladelphia, Pennsylvania  19131
Decatur Memorial HospitalDecatur, Illinois  62526
Tulane University Health Sciences CenterNew Orleans, Louisiana  70112
Virginia Commonwealth UniversityRichmond, Virginia  
Kaiser PermanentePortland, Oregon  97227
Frederick Memorial HospitalFrederick, Maryland  21701
Lankenau HospitalWynnewood, Pennsylvania  19096
Princeton Community HospitalPrinceton, West Virginia  24740
Holy Cross HospitalSilver Spring, Maryland  20910
Montana Cancer SpecialistsMissoula, Montana  59807-7877
Providence Saint Joseph Medical CenterBurbank, California  91505-4866
Memorial Health University Medical CenterSavannah, Georgia  31404
University of Chicago Comprehensive Cancer CenterChicago, Illinois  60637-1470
DeKalb Medical CenterDecatur, Georgia  30033
Northern Indiana Cancer Research ConsortiumSouth Bend, Indiana  
Hawaii Medical Center EastHonolulu, Hawaii  96817
Castle Medical CenterKailua, Hawaii  96734
Southeast Cancer CenterCape Girardeau, Missouri  63703
Clackamas Radiation Oncology CenterClackamas, Oregon  97015
Providence Newberg Medical CenterNewberg, Oregon  97132
Butler Memorial HospitalButler, Pennsylvania  16001
Littleton Adventist HospitalLittleton, Colorado  80122
Froedtert and the Medical College of WisconsinMilwaukee, Wisconsin  53226
Wake Forest University Health SciencesWinston-Salem, North Carolina  27157
OSF Saint Francis Medical CenterPeoria, Illinois  61637
Northside HospitalAtlanta, Georgia  30342
Saint Helena HospitalSaint Helena, California  94574
Saint Edward Mercy Medical CenterFt. Smith, Arkansas  72903
Mills - Peninsula HospitalsBurlingame, California  94010
Valley Medical Oncology Consultants-Castro ValleyCastro Valley, California  94546
Eden Hospital Medical CenterCastro Valley, California  94546
Valley Medical Oncology Consultants-FremontFremont, California  94538
Kaiser Permanente, FremontFremont, California  94538
Kaiser Permanente, HaywardHayward, California  94545
Bay Area Breast Surgeons IncOakland, California  94609
Bay Area Tumor Institution CCOPOakland, California  94609
Tom K Lee IncOakland, California  94609
Kaiser Permanente-OaklandOakland, California  94611
Valley Medical Oncology ConsultantsPleasanton, California  94588
Valley Care Health System - PleasantonPleasanton, California  94588
Kaiser Permanente-Redwood CityRedwood City, California  94063
Kaiser Permanente-RichmondRichmond, California  94801
Kaiser Permanente-RosevilleRoseville, California  95661
Kaiser Permanente-South SacramentoSacramento, California  95823
Kaiser Permanente - SacramentoSacramento, California  95825
Naval Medical Center -San DiegoSan Diego, California  92134
Kaiser Permanente-San FranciscoSan Francisco, California  94115
University of California San Francisco Medical Center-Mount ZionSan Francisco, California  94115
Kaiser Permanente-Santa Teresa-San JoseSan Jose, California  95119
Doctors Medical Center- JC Robinson Regional Cancer CenterSan Pablo, California  94806
Kaiser Permanente-San RafaelSan Rafael, California  94903
Kaiser Permanente-Santa RosaSanta Rosa, California  95403
Kaiser Permanente-South San FranciscoSouth San Francisco, California  94080
Kaiser Permanente-StocktonStockton, California  95210
Kaiser Permanente-VallejoVallejo, California  94589
Kaiser Permanente-Walnut CreekWalnut Creek, California  94596
The Medical Center of AuroraAurora, Colorado  80012
Penrose-Saint Francis HealthcareColorado Springs, Colorado  80907
Memorial Hospital Colorado SpringsColorado Springs, Colorado  80909
Saint Anthony Central HospitalDenver, Colorado  80204
Exempla Saint Joseph HospitalDenver, Colorado  80218
Colorado Cancer Research Program CCOPDenver, Colorado  80224-2522
Saint Mary's Hospital and Regional Medical CenterGrand Junction, Colorado  81502
Saint Mary Corwin Medical CenterPueblo, Colorado  81004
Saint Francis Hospital and Medical CenterHartford, Connecticut  06105
Middlesex HospitalMiddletown, Connecticut  06457
Bayhealth Medical Center at Kent GeneralDover, Delaware  19901
Lombardi Comprehensive Cancer Center at Georgetown UniversityWashington, District of Columbia  20057
Edna Williams Cancer Center at the Baptist Cancer InstituteJacksonville, Florida  32207
Atlanta Regional CCOPAtlanta, Georgia  30342
Well Star Cobb HospitalAustell, Georgia  30106
John B Amos Cancer CenterColumbus, Georgia  31904
Wellstar Kennestone HospitalMarietta, Georgia  30060
Saint Joseph's-Candler Health SystemSavannah, Georgia  31405
Oncare Hawaii Inc-POB IIHonolulu, Hawaii  96813
Oncare Hawaii Inc-KuakiniHonolulu, Hawaii  96817
University of HawaiiHonolulu, Hawaii  96813
Pacific Cancer Institute of MauiWailuku, Hawaii  96793
Saint Luke's Mountain States Tumor InstituteBoise, Idaho  83712
Rush - Copley Medical CenterAurora, Illinois  60504
John H Stroger Jr Hospital of Cook CountyChicago, Illinois  60612-3785
Cancer Institute at Alexian BrothersElk Grove Village, Illinois  60007
Saint Francis HospitalEvanston, Illinois  60202
Intercommunity Cancer CenterGalesburg, Illinois  61401
Hopedale Medical Complex - HospitalHopedale, Illinois  61747
Joliet Oncology-Hematology Associates LimitedJoliet, Illinois  60435
Provena Saint Mary's HospitalKankakee, Illinois  60901
Community Cancer Center FoundationNormal, Illinois  61761
Illinois CancerCare-Ottawa ClinicOttawa, Illinois  61350
Ottawa Regional Hospital and Healthcare CenterOttawa, Illinois  61350
Pekin Cancer Treatment CenterPekin, Illinois  61554
Illinois Oncology Research Association CCOPPeoria, Illinois  61615
Illinois CancerCare-PeoriaPeoria, Illinois  61615
Illinois Valley HospitalPeru, Illinois  61354
West Suburban Cancer CenterRiver Forest, Illinois  60305
Saint Margaret's HospitalSpring Valley, Illinois  61362
Carle Clinic-Urbana MainUrbana, Illinois  61801
Saint Francis Hospital and Health CentersBeech Grove, Indiana  46107
Fort Wayne Medical Oncology and Hematology Inc - State BoulevardFort Wayne, Indiana  46845
Saint Vincent Hospital and Health ServicesIndianapolis, Indiana  46260
Saint Anthony Memorial Health CenterMichigan City, Indiana  46360
Reid Hospital and Health Care ServicesRichmond, Indiana  47374
McFarland ClinicAmes, Iowa  50010
Hematology Oncology Associates-Quad CitiesBettendorf, Iowa  52722
Cedar Rapids Oncology AssociationCedar Rapids, Iowa  52403
Mercy HospitalCedar Rapids, Iowa  52403
Medical Oncology and Hematology Associates-West Des MoinesClive, Iowa  50325
Genesis Medical Center - East CampusDavenport, Iowa  52803
Iowa Oncology Research Association CCOPDes Moines, Iowa  50309
Mercy CapitolDes Moines, Iowa  50307
Mercy Medical Center - Des MoinesDes Moines, Iowa  50314
Medical Oncology and Hematology Associates-Des MoinesDes Moines, Iowa  50309
Mercy Medical Center - North IowaMason City, Iowa  50401
Mercy Medical Center-Sioux CitySioux City, Iowa  51104
Saint Luke's Regional Medical CenterSioux City, Iowa  51104
Covenant Medical CenterWaterloo, Iowa  50702
Cancer Center of Kansas - El DoradoEl Dorado, Kansas  67042
Cancer Center of Kansas-KingmanKingman, Kansas  67068
Cancer Center of Kansas - ParsonsParsons, Kansas  67357
Cancer Center of Kansas - PrattPratt, Kansas  67124
Cancer Center of Kansas-Wichita Medical Arts TowerWichita, Kansas  67208
Cancer Center of Kansas - Main OfficeWichita, Kansas  67214
Ochsner Clinic Foundation-Baton RougeBaton Rouge, Louisiana  70809
Ochsner Clinic CCOPNew Orleans, Louisiana  70121
Holy Family HospitalMethuen, Massachusetts  01844
North Shore Medical Center Cancer CenterPeabody, Massachusetts  01960
Hickman Cancer CenterAdrian, Michigan  49221
Michigan Cancer Research Consortium Community Clinical Oncology ProgramAnn Arbor, Michigan  48106
Oakwood HospitalDearborn, Michigan  48123
Saint John Hospital and Medical CenterDetroit, Michigan  48236
Green Bay Oncology - EscanabaEscanaba, Michigan  49431
Grand Rapids Clinical Oncology ProgramGrand Rapids, Michigan  49503
Saint Mary's Health CareGrand Rapids, Michigan  49503
Spectrum Health at Butterworth CampusGrand Rapids, Michigan  49503
Green Bay Oncology - Iron MountainIron Mountain, Michigan  49801
Allegiance HealthJackson, Michigan  49201
Sparrow HospitalLansing, Michigan  48912
Saint Mary Mercy HospitalLivonia, Michigan  48154
Mid-Michigan Medical Center - MidlandMidland, Michigan  48670
Mercy Memorial HospitalMonroe, Michigan  48162
Mercy Health Partners-Mercy CampusMuskegon, Michigan  49443
Northern Michigan Regional HospitalPetoskey, Michigan  49770
Saint Joseph Mercy OaklandPontiac, Michigan  48341-2985
Saint Joseph Mercy Port HuronPort Huron, Michigan  48060
Saint Mary's of MichiganSaginaw, Michigan  48601
Lakeland HospitalSt. Joseph, Michigan  49085
Saint John Macomb-Oakland HospitalWarren, Michigan  48093
Medini, Eitan MD (UIA Investigator)Alexandria, Minnesota  56308
Miller-Dwan HospitalDuluth, Minnesota  55805
Etzell, Paul S MD (UIA Investigator)Fergus Falls, Minnesota  56537
Swenson, Wade II, MD (UIA Investigator)Fergus Falls, Minnesota  56537
Unity HospitalFridley, Minnesota  55432
Immanuel-Saint Joseph Hospital-Mayo Health SystemMankato, Minnesota  56002
Saint John's Hospital - HealtheastMaplewood, Minnesota  55109
Minnesota Oncology Hematology PA-MaplewoodMaplewood, Minnesota  55109
North Memorial Medical Health CenterRobbinsdale, Minnesota  55422
Saint Cloud HospitalSaint Cloud, Minnesota  56303
Park Nicollet Clinic - Saint Louis ParkSaint Louis Park, Minnesota  55416
Minnesota Oncology and Hematology PA-WoodburyWoodbury, Minnesota  55125
Saint Luke's Hospital of Kansas CityKansas City, Missouri  64111
Saint Joseph Health CenterKansas City, Missouri  64114
Truman Medical CenterKansas City, Missouri  64108
Missouri Baptist Medical CenterSaint Louis, Missouri  63131
Ozark Health Ventures LLC dba Cancer Research for The Ozarks SpringfieldSpringfield, Missouri  65802
Saint John's HospitalSpringfield, Missouri  65804
Cox Medical CenterSpringfield, Missouri  65807
Hematology-Oncology Centers of the Northern Rockies PCBillings, Montana  59101
Saint Vincent HealthcareBillings, Montana  59101
Billings ClinicBillings, Montana  59107-7000
Saint James Community Hospital and Cancer Treatment CenterButte, Montana  59701
Benefis Healthcare- Sletten Cancer InstituteGreat Falls, Montana  59405
Berdeaux, Donald MD (UIA Investigator)Great Falls, Montana  59405
Saint Peter's Community HospitalHelena, Montana  59601
Glacier Oncology PLLCKalispell, Montana  59901
Community Medical HospitalMissoula, Montana  59801
Saint Patrick Hospital - Community HospitalMissoula, Montana  59802
Good Samaritan HospitalKearney, Nebraska  68847
Lincoln Medical Education Foundation Cancer Resource CenterLincoln, Nebraska  68510
Missouri Valley Cancer Consortium CCOPOmaha, Nebraska  68106
Nevada Cancer Research Foundation CCOPLas Vegas, Nevada  89106
Exeter HospitalExeter, New Hampshire  03833
New Hampshire Oncology Hematology AssociatesHooksett, New Hampshire  03106
Cheshire Medical Center-Dartmouth-Hitchcock KeeneKeene, New Hampshire  03431
LRGHealthcare-Lakes Region General HospitalLaconia, New Hampshire  03246
Cooper Hospital University Medical CenterCamden, New Jersey  08103
Hunterdon Medical CenterFlemington, New Jersey  08822
Sparta Cancer Treatment CenterSparta, New Jersey  07871
South Jersey HealthcareVineland, New Jersey  08360
Adirondack Cancer CenterGlens Falls, New York  12801
State University of New York Upstate Medical UniversitySyracuse, New York  13210
Faxton-Saint Luke's HealthcareUtica, New York  13502
Mission Hospitals IncAsheville, North Carolina  28801
Alamance Regional Medical CenterBurlington, North Carolina  27216
Wayne Memorial HospitalGoldsboro, North Carolina  27534
Margaret R Pardee Memorial HospitalHendersonville, North Carolina  28791
Kinston Medical Specialists PAKinston, North Carolina  28501
Marion L Shepard Cancer CenterWashington, North Carolina  27889
Saint Alexius Medical CenterBismarck, North Dakota  58501
Summa Barberton HospitalBarberton, Ohio  44203
Aultman Health FoundationCanton, Ohio  44710
Doctors HospitalColumbus, Ohio  43228
Grant Medical CenterColumbus, Ohio  43215
Mount Carmel Health Center WestColumbus, Ohio  43222
Good Samaritan Hospital - DaytonDayton, Ohio  45406
Dayton CCOPDayton, Ohio  45429
Samaritan North Health CenterDayton, Ohio  45415
Hematology Oncology Center IncorporatedElyria, Ohio  44035
Blanchard Valley HospitalFindlay, Ohio  45840
Atrium Medical Center-Middletown Regional HospitalFranklin, Ohio  45005-1066
Kettering Medical CenterKettering, Ohio  45429
Saint Rita's Medical CenterLima, Ohio  45801
Marietta Memorial HospitalMarietta, Ohio  45750
Toledo Radiation Oncology at Northwest Ohio Onocolgy CenterMaumee, Ohio  43537
Saint Charles HospitalOregon, Ohio  43616
North Coast Cancer CareSandusky, Ohio  44870
Toledo Community Hospital Oncology Program CCOPToledo, Ohio  43617
Mercy Cancer Center at Saint Anne Mercy HospitalToledo, Ohio  43623
University of ToledoToledo, Ohio  43614
Saint Vincent Mercy Medical CenterToledo, Ohio  43608
Upper Valley Medical CenterTroy, Ohio  45373
Saint Ann's HospitalWesterville, Ohio  43081
Wright-Patterson Medical CenterWright-Patterson Afb, Ohio  45433-5529
Genesis HealthCare SystemZanesville, Ohio  43701
Natalie W Bryant Cancer CenterTulsa, Oklahoma  74136
Legacy Good Samaritan Hospital and Medical CenterPortland, Oregon  97210
Providence Saint Vincent Medical CenterPortland, Oregon  97225
Columbia River Oncology ProgramPortland, Oregon  97225
Ephrata Cancer CenterEphrata, Pennsylvania  17522
Riddle HospitalMedia, Pennsylvania  19063
Pottstown Memorial Medical CenterPottstown, Pennsylvania  19464
Saint Joseph Medical CenterReading, Pennsylvania  19605
Hematology and Oncology Associates of North East PennsylvaniaScranton, Pennsylvania  18508
Scranton Hematology OncologyScranton, Pennsylvania  18510
Mercy HospitalScranton, Pennsylvania  18501
Associates In Hematology Oncology PC-UplandUpland, Pennsylvania  19013
Geisinger Wyoming ValleyWilkes-Barre, Pennsylvania  18711
Mainline Health CCOPWynnewood, Pennsylvania  19096
AnMed Health HospitalAnderson, South Carolina  29621
Greenville CCOPGreenville, South Carolina  29615
Greenville Memorial HospitalGreenville, South Carolina  29605
Upstate Carolina CCOPSpartanburg, South Carolina  29303
Conklin Regional Cancer CenterAberdeen, South Dakota  57401
Sanford Cancer Center-Oncology ClinicSioux Falls, South Dakota  57104
Fredericksburg Oncology IncFredericksburg, Virginia  22401
Saint Francis HospitalFederal Way, Washington  98003
Providence - Saint Peter HospitalOlympia, Washington  98506-5166
Good Samaritan Community HospitalPuyallup, Washington  98372
Northwest CCOPTacoma, Washington  98405
Multicare Health SystemTacoma, Washington  98415
Saint Clare HospitalTacoma, Washington  98499
Saint Joseph Medical CenterTacoma, Washington  98405
Edwards Comprehensive Cancer CenterHuntington, West Virginia  25701
Saint Vincent HospitalGreen Bay, Wisconsin  54301
Green Bay Oncology Limited at Saint Mary's HospitalGreen Bay, Wisconsin  54303
Saint Mary's HospitalGreen Bay, Wisconsin  54303
Green Bay Oncology at Saint Vincent HospitalGreen Bay, Wisconsin  54301-3526
Aurora BayCare Medical CenterGreen Bay, Wisconsin  54311-6519
Dean Hematology and Oncology ClinicMadison, Wisconsin  53717
Vince Lombardi Cancer Clinic-MarinetteMarinette, Wisconsin  54143
Bay Area Medical CenterMarinette, Wisconsin  54143
Marshfield Clinic-Minocqua CenterMinocqua, Wisconsin  54548
Oconomowoc Memorial Hospital-ProHealth Care IncOconomowoc, Wisconsin  53066-3896
Green Bay Oncology - Oconto FallsOconto Falls, Wisconsin  54154
Marshfield Clinic at James Beck Cancer CenterRhinelander, Wisconsin  54501
Marshfield Clinic-Rice Lake CenterRice Lake, Wisconsin  54868
Green Bay Oncology - Sturgeon BaySturgeon Bay, Wisconsin  54235
Women and Infants HospitalProvidence, Rhode Island  02905
Lynn Regional Cancer Center - WestBoca Raton, Florida  33428
Jupiter Medical CenterJupiter, Florida  33458
Gainesville Hematology Oncology AssociatesGainesville, Florida  32605
University of IllinoisChicago, Illinois  60612
Elkhart ClinicElkhart, Indiana  46515
Marin General HospitalGreenbrae, California  94904
Memorial Healthcare System - Joe DiMaggio Children's HospitalHollywood, Florida  33021
Mount Sinai Medical Center CCOPMiami Beach, Florida  33140
Northeast Georgia Cancer Care LLCAthens, Georgia  30607
Harbin Clinic Medical Oncology and Clinical ResearchRome, Georgia  30165
Illinois CancerCare-BloomingtonBloomington%, Illinois  61701
Illinois CancerCare-CantonCanton, Illinois  61520
Illinois CancerCare-CarthageCarthage, Illinois  62321
Illinois CancerCare-EurekaEureka, Illinois  61530
Illinois CancerCare-CottageGalesburg, Illinois  61401
Illinois CancerCare-HavanaHavana, Illinois  62644
Illinois CancerCare-Kewanee ClinicKewanee, Illinois  61443
Illinois CancerCare-MacombMacomb, Illinois  61455
Illinois CancerCare-MonmouthMonmouth, Illinois  61462
Illinois CancerCare-Community Cancer CenterNormal, Illinois  61761
Illinois CancerCare-PekinPekin, Illinois  61603
Illinois CancerCare-PeruPeru, Illinois  61354
Illinois CancerCare-PrincetonPrinceton, Illinois  61356
Illinois CancerCare-Spring ValleySpring Valley, Illinois  61362
Michiana Hematology Oncology PC-ElkhartElkhart, Indiana  46514
Michiana Hematology Oncology PC-PlymouthPlymouth, Indiana  46563
Michiana Hematology Oncology PC-South BendSouth Bend, Indiana  46601
Michiana Hematology Oncology-PC WestvilleWestville, Indiana  46391
Cancer Center of Kansas-LiberalLiberal, Kansas  67901
The Memorial Hospital at EastonEaston, Maryland  21601
Michiana Hematology Oncology PC-NilesNiles, Michigan  49120
Central Care Cancer Center-Carrie J Babb Cancer CenterBolivar, Missouri  65613
Skaggs Cancer CenterBranson, Missouri  65616
University of Missouri - Ellis FischelColumbia, Missouri  65203
Hackensack University Medical CCOPHackensack, New Jersey  07601
UMDNJ - New Jersey Medical SchoolNewark, New Jersey  07103
AtlantiCare Regional Medical Center -Main CampusPomona, New Jersey  08240
Moses Cone Health System-Regional Cancer CenterGreensboro, North Carolina  27403
Maria Parham HospitalHenderson, North Carolina  27536
Rex Cancer CenterRaleigh, North Carolina  27607
Duke Raleigh HospitalRaleigh, North Carolina  27609
Annie Penn Memorial HospitalReidsville, North Carolina  27320
North Coast Cancer Care-ClydeClyde, Ohio  43410
Community Health Partners Regional Medical CenterElyria, Ohio  44035
Oncology Hematology Associates of Northern PennsylvaniaDubois, Pennsylvania  15801
Cancer Centers of the Carolinas - FarisGreenville, South Carolina  29605
Cancer Centers of the Carolinas-Greer Radiation OncologyGreer, South Carolina  29650
Cancer Centers of the Carolinas-Greer Medical OncologyGreer, South Carolina  29650
University of Tennessee - KnoxvilleKnoxville, Tennessee  37920
Nashville Oncology Associates PCNashville, Tennessee  37203
Virginia Oncology Associates-HamptonHampton, Virginia  23666
Marshfield Clinic-Chippewa CenterChippewa Falls, Wisconsin  54729
Holy Family Memorial HospitalManitowoc, Wisconsin  54221
Aurora Advanced Healthcare Inc-MequonMequon, Wisconsin  53092
Vince Lombardi Cancer Clinic-SheboyganSheboygan, Wisconsin  53081
Marshfield Clinic Cancer Care at Saint Michael's HospitalStevens Point, Wisconsin  54481
Aurora Medical Center in SummitSummit, Wisconsin  53066
Vince Lombardi Cancer ClinicTwo Rivers, Wisconsin  54241
Monter Cancer CenterLake Success, New York  11042
FirstHealth of the Carolinas-Moore Regional HosiptalPinehurst, North Carolina  28374
Cancer Centers of Southwest Oklahoma ResearchLawton, Oklahoma  
Kaiser Anaheim Medical CenterAnaheim, California  92807
Kaiser Permanente-Deer Valley Medical CenterAntioch, California  94531
Kaiser Permanente Medical Group - Baldwin ParkBaldwin Park, California  91706
Kaiser Foundation HospitalBellflower, California  90706
Kaiser Permanente HospitalFontana, California  92335
Kaiser Permanente - Harbor CityHarbor City, California  90710
Kaiser Permanente-West Los AngelesLos Angeles, California  90034
Kaiser Permanente - Panorama CityPanorama City, California  91402
Palchak David MDPismo Beach, California  93449
Salinas Valley MemorialSalinas, California  93901
Kaiser Permanente at San DiegoSan Diego, California  92120
Kaiser Permanente Health CareSan Marcos, California  92069
Kaiser Permanente Medical Center-VacavilleVacaville, California  95688
Kaiser Permanente-Rock CreekLafayette, Colorado  80026
Kaiser Permanente Moanalua Medical CenterHonolulu, Hawaii  96819
Wilcox Memorial Hospital and Kauai Medical ClinicLihue, Hawaii  96766-1099
OSF Saint Francis Medical Center Radiation Oncology Service at the Central Illinois Comprehensive CCPeoria, Illinois  61615-7827
Saint Luke's South HospitalOverland Park, Kansas  66213
Kansas City CCOPPrairie Village, Kansas  66208
Doctors Carrol, Sheth, RaghavanLouisville, Kentucky  40215
Hematology and Oncology ClinicBaton Rouge, Louisiana  70809
Ochsner North Shore Medical CenterCovington, Louisiana  70433
Capital Region Medical Center-Goldschmidt Cancer CenterJefferson City, Missouri  65109
Heartland Hematology and Oncology Associates IncorporatedKansas City, Missouri  64118
Saint Joseph Oncology IncSaint Joseph, Missouri  64507
Comprehensive Cancer Care PCSaint Louis, Missouri  63141
Coney Island HospitalBrooklyn, New York  11235
Southern Ohio Medical CenterPortsmouth, Ohio  45662
Cancer Care Associates-MercyOklahoma City, Oklahoma  73120
Asante Health SystemMedford, Oregon  97504
Rogue Valley Medical CenterMedford, Oregon  97504
Saint Francis HospitalGreenville, South Carolina  29601
Hematology Oncology Associates of Fredericksburg IncFredericksburg, Virginia  22401
Memorial Hospital Of MartinsvilleMartinsville, Virginia  24115
Gundersen LutheranLa Crosse, Wisconsin  54601
Saint Nicholas HospitalMadison, Wisconsin  53715
Columbia Saint Mary's Water Tower Medical CommonsMilwaukee, Wisconsin  53211
Sparks Regional Medical CenterFort Smith, Arkansas  72901
Lexington Medical CenterWest Columbia, South Carolina  29169
San Francisco General HospitalSan Francisco, California  94110
Kaiser Permanente-FranklinDenver, Colorado  80205
Beaufort Memorial HospitalBeaufort, South Carolina  29902
Siouxland Hematology Oncology AssociatesSioux City, Iowa  51101
Walter Reed National Military Medical CenterBethesda, Maryland  20889
Kaiser Permanente-MissionSan Diego, California  92108
Norris Cotton Cancer Center-ManchesterManchester, New Hampshire  03104
Dublin Hematology Oncology Care PCDublin, Georgia  31021
IU Health ArnettLafayette, Indiana  
Georgia Health Sciences UniversityAugusta, Georgia  30912
Alta Bates Summit Medical Center-Herrick CampusBerkeley, California  94704
Carle Foundation - Carle Cancer CenterUrbana, Illinois  61801
Michiana Hematology Oncology PC-MishawakaMishawaka, Indiana  46545-1470
Oncology Associates at Mercy Medical CenterCedar Rapids, Iowa  52403
Marie Yeager Cancer CenterSaint Joseph, Michigan  49085
The Dana-Farber Cancer Institute at LondonderryLondonderry, New Hampshire  03053
Hematology Oncology Associates of Central New York PCEast Syracuse, New York  13057
Sanford Clinic North-FargoFargo, North Dakota  58102
Sanford Medical Center-FargoFargo, North Dakota  58122
Summa Akron City HospitalAkron, Ohio  44304
Roy and Patricia Disney Family Cancer CenterBurbank, California  91505
Indiana University Health Goshen Center For Cancer CareGoshen, Indiana  46526
The Toledo Hospital/Toledo Children's HospitalToledo, Ohio  43606
Sanford USD Medical Center - Sioux FallsSioux Falls, South Dakota  57117-5134
Providence Sacred Heart Medical Center and Children's HospitalSpokane, Washington  99204
North Shore-LIJ Health System CCOPManhasset, New York  11030
Genesys Regional Medical Center-West Flint CampusFlint, Michigan  48532
Sanford Clinic North-BemidgiBemidji, Minnesota  56601
Essentia Health Duluth Clinic CCOPDuluth, Minnesota  55805
Essentia Health Saint Mary's Medical CenterDuluth, Minnesota  55805
Sanford Bismarck Medical CenterBismarck, North Dakota  58501
Toledo Clinic Cancer Centers-OregonOregon, Ohio  43616
Geisinger Medical Center-Cancer Center HazeltonHazleton, Pennsylvania  18201
Community Howard Regional HealthKokomo, Indiana  46904
Indiana University Health La Porte HospitalLa Porte, Indiana  46350
Saint Joseph Regional Medical Center-MishawakaMishawaka, Indiana  46545-1470
Via Christi Hospital-PittsburgPittsburg, Kansas  66762
Essentia Health Cancer Center-South University ClinicFargo, North Dakota  58103
Aurora Cancer Care-BurlingtonBurlington, Wisconsin  53105
Aurora Cancer Care-FranklinFranklin, Wisconsin  53132
Aurora Cancer Care-GlendaleGlendale, Wisconsin  53212
Aurora Cancer Care-Kenosha SouthKenosha, Wisconsin  53142
Aurora Cancer Care-Milwaukee SouthMilwaukee, Wisconsin  53215
Aurora Cancer Care-RacineRacine, Wisconsin  53406-5661
Aurora Cancer Care-WaukeshaWaukesha, Wisconsin  53188
Aurora Cancer Care-Milwaukee WestWauwatosa, Wisconsin  53226
Christiana Care Health System-Christiana HospitalNewark, Delaware  19718
Bronson Battle CreekBattle Creek, Michigan  49017
Riverview Medical Center/Booker Cancer CenterRed Bank, New Jersey  07701
Springfield Regional Medical CenterSpringfield, Ohio  45505
NEA Baptist Memorial HospitalJonesboro, Arkansas  72401
Marin Cancer Care IncGreenbrae, California  94904
Lake Region Healthcare Corporation-Cancer CareFergus Falls, Minnesota  56537
Toledo Clinic Cancer Centers-Bowling GreenBowling Green, Ohio  43402
Toledo Clinic Cancer Centers-MaumeeMaumee, Ohio  43537-1839
Toledo Clinic Cancer Centers-ToledoToledo, Ohio  43623
Guthrie Clinic-Robert Packer HospitalSayre, Pennsylvania  18840
Self Regional HealthcareGreenwood, South Carolina  29646
Providence Holy Family HospitalSpokane, Washington  99208
PeaceHealth Southwest Medical CenterVancouver, Washington  98664
Aurora Cancer Care-Southern LakesElkhorn, Wisconsin  53121
Mayo Clinic Health System-Franciscan HealthcareLa Crosse, Wisconsin  54601
Halifax Health Medical Center-Centers for OncologyDaytona Beach, Florida  32114
Maine Center for Cancer Medicine and Blood Disorders-ScarboroughScarborough, Maine  04074
Ochsner Baptist Medical CenterNew Orleans, Louisiana  70115
Cancer Care Associates-NormanNorman, Oklahoma  73071
Mercy Physicians of Oklahoma-LakesideOklahoma City, Oklahoma  73120
Providence Willamette Falls Medical CenterOregon City, Oregon  97045
Medical Oncology Hematology Associates of Northern Virginia LimitedFairfax, Virginia  22031
Nash General HospitalRocky Mount, North Carolina  27804
Associated Medical Specialists PA dba Coastal Cancer CenterMyrtle Beach, South Carolina  29572
D N Greenwald CenterMukwonago, Wisconsin  53149