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A Randomized Phase III Trial of Weekly Paclitaxel Compared to Weekly Nanoparticle Albumin Bound Nab-Paclitaxel or Ixabepilone With or Without Bevacizumab as First-line Therapy for Locally Recurrent or Metastatic Breast Cancer

Phase 3
18 Years
Open (Enrolling)
Male Breast Cancer, Recurrent Breast Cancer, Stage IIIC Breast Cancer, Stage IV Breast Cancer

Thank you

Trial Information

A Randomized Phase III Trial of Weekly Paclitaxel Compared to Weekly Nanoparticle Albumin Bound Nab-Paclitaxel or Ixabepilone With or Without Bevacizumab as First-line Therapy for Locally Recurrent or Metastatic Breast Cancer


I. To compare the progression-free survival of patients with stage IIIC or IV breast cancer
treated with paclitaxel albumin-stabilized nanoparticle formulation (nab-paclitaxel) versus
ixabepilone versus paclitaxel with or without bevacizumab.


I. To compare the objective response rate, duration of response, and time to treatment
failure in patients receiving nab-paclitaxel versus paclitaxel, and to separately compare
these endpoints in patients receiving ixabepilone versus paclitaxel.

II. To compare the 12-month rate of progression in patients treated with these regimens.

III. To compare treatment-related toxicities in patients receiving these regimens, according
to the rates of grade 3/4 sensory neuropathy and the rates of peripheral neuropathy assessed
by the FACT/GOG neurotoxicity subscale.

IV. To compare overall survival of patients receiving these regimens. V. To prospectively
collect data on sociodemographics, non-cancer morbidities, and receipt of post-trial therapy
to evaluate the role of potential disparities on survival from cancer.

VI. To evaluate the relationships between SPARC overexpression and changes in blood levels
of caveolin-1 (Cav-1) to PFS and secondary endpoints of response during treatment in these

V. To evaluate the relationships between changes in blood levels of circulating tumor cells
(CTCs) and circulating endothelial cells (CECs) to PFS and secondary endpoints of response
during treatment in these patients.

VII. To evaluate the association of expression levels of the microtubule associated proteins
tau and beta-tubulin isotype composition with PFS and secondary endpoints of response during

VIII. To investigate a potential CYP2C8*2/*3 by paclitaxel interaction with respect to
progression-free survival (PFS).

IX. To determine if CYP2C8*2 and CPY2C8*3 are associated with paclitaxel-induced peripheral

X. To perform exploratory analysis of CYP3A4, CYP3A5, ABCB1 and ABCC2 polymorphisms with
response and toxicity profiles.

XI. To prospectively collect data on sociodemographics, non-cancer morbidities, and receipt
of post-trial therapy to evaluate the role of potential disparities on survival from cancer.

XII. To evaluate the relationship between physical activity behaviors at the time of study
enrollment and progression-free and overall survival.

XIII. To identify baseline factors that predict the risk of grade 3, 4, or 5 toxicity in
patients receiving treatment with weekly paclitaxel, nab-paclitaxel, or ixabepilone combined
with or without bevacizumab.

XIV. To perform an exploratory analysis of whether other factors included in patient
assessments (either individually or in combination) predict the risk of grade 3, 4, or 5
toxicity in patients receiving weekly paclitaxel, nab-paclitaxel, or ixabepilone combined
with or without bevacizumab, with a specific focus on the relationship between pre-existing
hypertension or neuropathy. (Exploratory) XV. To compare the associations of baseline
factors to grade 3, 4, or 5 toxicity in patients receiving weekly paclitaxel,
nab-paclitaxel, or ixabepilone combined with or without bevacizumab.

XVI. To explore whether longitudinal changes in factors are in association with the
occurrence of grade 3, 4, or 5 toxicities in patients with weekly paclitaxel, nabpaclitaxel,
or ixabepilone combined with or without bevacizumab. (Exploratory) XVII. To explore the
association between grade 2-4 neuropathy and longitudinal changes in the following
functional status measures: a) OARS MFAQ (IADL); b) MOS Physical Functioning; c) Karnofsky
Performance Status Rated Healthcare Professional; d) Timed "Up and Go"; e) OARS Physical
Health Section.


OUTLINE: This is a multicenter study. Patients are stratified according to taxane as
adjuvant therapy (yes or no), estrogen receptor (ER) or progesterone receptor (PgR) status
(ER-positive or PgR-positive vs both ER-negative and PgR-negative), physician's decision to
use bevacizumab (yes vs no). Patients are randomized to 1 of 3 treatment arms.

ARM I: (weekly paclitaxel) Patients receive paclitaxel IV over 1 hour on days 1, 8, and 15.
Patients may also receive bevacizumab IV over 30-90 minutes on days 1 and 15.

ARM II: (weekly paclitaxel albumin-stabilized nanoparticle formulation [nab-paclitaxel])
Patients receive nab-paclitaxel IV over 30 minutes on days 1, 8, and 15. Patients may also
receive bevacizumab as in arm I.

ARM III: (weekly ixabepilone) Patients receive ixabepilone IV over 60 minutes on days 1, 8,
and 15. Patients may also receive bevacizumab as in arm I.

In all arms, treatment repeats every 28 days in the absence of disease progression or
unacceptable toxicity. Patients complete questionnaires about peripheral neuropathy at
baseline and before each course of therapy. They also complete questionnaires about
sociodemographics, non-cancer comorbidities, social support, physical activity, and
post-trial therapy at baseline and periodically thereafter. Blood samples may be collected
at baseline and periodically during study for correlative studies. Tumor tissue samples from
diagnosis may be also collected.

After completion of study therapy, patients are followed every 6 months for 2 years and then
annually for up to 3 years.

Inclusion Criteria:

- Histologically confirmed invasive breast cancer

- Stage IIIC or IV (locally recurrent or metastatic) disease not amenable to local

- Measurable disease (target lesions), defined as ≥ 1 lesion that can be accurately
measured in ≥ 1 dimension (longest diameter to be recorded) as ≥ 2.0 cm with
conventional techniques or as ≥ 1 cm with spiral CT scan

- No non-measurable lesions, including any of the following:

- Ascites

- Pleural/pericardial effusion

- Inflammatory breast disease

- Lymphangitis cutis/pulmonitis

- Bone lesions

- Leptomeningeal disease

- Cystic lesions

- Abdominal masses not confirmed and followed by imaging techniques

- HER2/neu status must be known

- HER2-positive disease allowed provided patient received prior trastuzumab
(Herceptin®) or lapatinib (documentation of progression on HER2-directed therapy
is not required)

- No progressing or untreated CNS metastases or leptomeningeal disease

- History of resected brain metastases with stable MRI scans for 3 months,
including within the past 4 weeks allowed

- History of gamma-knife radiosurgery or whole-brain radiation with stable MRI
scans for 3 months, including within the past 4 weeks allowed

- Hormone receptor status must be known

- Estrogen receptor (ER)- and progesterone receptor (PgR)-positive if ≥ 1% cells
are positive

- Menopausal status not specified

- ECOG (Zubrod) performance status 0-1

- Life expectancy ≥ 12 weeks

- Granulocytes ≥ 1,500/μL

- Platelet count ≥ 100,000/μL

- Creatinine ≤ 2.0 mg/dL

- Bilirubin < 1.5 mg/dL (unless due to Gilbert's syndrome)

- AST and ALT ≤ 2.5 times upper limit of normal

- Urine protein ≤ 1+ OR urine protein: creatinine ratio < 1

- Patients with proteinuria ≥ 2+ at baseline must undergo a 24-hoururine
collection that demonstrates < 1 g of protein/24 hr or UPC ratio ≤ 1

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception

- History of seizures allowed if well controlled with standard medication

- No history of hypersensitivity to paclitaxel or Cremophor® EL CTCAE grade ≥ 3

- No other active malignancy except nonmelanoma skin cancer (patients are not
considered to have a "currently active" malignancy if they have completed therapy and
are considered by their physician to have less than 30% risk of relapse)

- No history of abdominal fistula or intra-abdominal abscess within 6 months prior to
study registration

- No history of gastrointestinal (GI) perforation within the past 12 months

- No history of significant bleeding episodes (e.g., hemoptysis, upper or lower GI
bleeding) within the past 6 months

- No history of stroke or transient ischemic attack within the past 6 months

- No history of clinically significant cardiovascular disease including any of the

- Uncontrolled hypertension, defined as systolic blood pressure (BP) > 150 mm Hg
and/or diastolic BP > 90 mm Hg on antihypertensive medications

- Prior history of hypersensitivity or hypertensive encephalopathy

- History of myocardial infarction or unstable angina within past 6 months

- NYHA congestive heart failure class II-IV

- Symptomatic peripheral vascular disease

- Significant vascular disease (e.g., aortic aneurysm or aortic dissection) or
arterial thrombotic events

- No serious, non-healing wound, ulcer, or bone fracture

- No significant traumatic injury in the past 28 days

- No peripheral neuropathy ≥ grade 2

- Concurrent full-dose anticoagulants allowed but patient must be on a stable dose of
warfarin or low molecular weight heparin

- Anti-platelet therapy or on daily prophylactic-dose aspirin allowed

- Stable doses of anticoagulation for atrial fibrillation allowed

- No prior chemotherapy regimen for metastatic disease

- Adjuvant or neoadjuvant taxane allowed provided interval between completion of
adjuvant therapy and disease recurrence is ≥ 12 months

- At least 2 weeks since prior radiotherapy

- At least 28 days since prior major surgical procedure or open biopsy and fully

- There are no restrictions on core biopsies, placement of a vascular access
device, or other minor procedures prior to registration.

- At least 7 days since prior hormonal therapy

- Any number of prior hormonal therapies allowed

- Prior trastuzumab or lapatinib ditosylate for HER2-overexpressing tumors allowed

- Prior bevacizumab allowed

- Prior and concurrent bisphosphonate treatment allowed

- No concurrent major surgical procedure

- No concurrent palliative radiotherapy

- No concurrent aprepitant

- No concurrent pegfilgrastim

- No other concurrent chemotherapy or anticancer hormone therapy

Type of Study:


Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Progression-free survival (PFS) of each experimental arm to the PFS of the control arm

Outcome Description:

The primary analysis will use the stratified log-rank tests to identify differences in PFS for each experimental arm as compared to control arm (based upon the trial's stratification factors: prior adjuvant taxanes, hormone receptor status, and concomitant bevacizumab). Any efficacy claim will be based solely on this primary statistical analysis. As a secondary analysis we will use the stratified log-rank test to test for a difference between arms after adjusting for disease-free interval and visceral metastases versus bone/soft tissue metastases.

Outcome Time Frame:

Time from randomization to progression or death due to any cause, whichever occurs first, assessed up to 5 years

Safety Issue:


Principal Investigator

Hope Rugo

Investigator Role:

Principal Investigator

Investigator Affiliation:

Cancer and Leukemia Group B


United States: Food and Drug Administration

Study ID:




Start Date:

October 2008

Completion Date:

Related Keywords:

  • Male Breast Cancer
  • Recurrent Breast Cancer
  • Stage IIIC Breast Cancer
  • Stage IV Breast Cancer
  • Breast Neoplasms
  • Breast Neoplasms, Male



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Saint Francis Hospital and Medical Center Hartford, Connecticut  06105
Middlesex Hospital Middletown, Connecticut  06457
Bayhealth Medical Center at Kent General Dover, Delaware  19901
Lombardi Comprehensive Cancer Center at Georgetown University Washington, District of Columbia  20057
Edna Williams Cancer Center at the Baptist Cancer Institute Jacksonville, Florida  32207
Atlanta Regional CCOP Atlanta, Georgia  30342
Well Star Cobb Hospital Austell, Georgia  30106
John B Amos Cancer Center Columbus, Georgia  31904
Wellstar Kennestone Hospital Marietta, Georgia  30060
Saint Joseph's-Candler Health System Savannah, Georgia  31405
Oncare Hawaii Inc-POB II Honolulu, Hawaii  96813
Oncare Hawaii Inc-Kuakini Honolulu, Hawaii  96817
University of Hawaii Honolulu, Hawaii  96813
Pacific Cancer Institute of Maui Wailuku, Hawaii  96793
Saint Luke's Mountain States Tumor Institute Boise, Idaho  83712
Rush - Copley Medical Center Aurora, Illinois  60504
John H Stroger Jr Hospital of Cook County Chicago, Illinois  60612-3785
Cancer Institute at Alexian Brothers Elk Grove Village, Illinois  60007
Saint Francis Hospital Evanston, Illinois  60202
Intercommunity Cancer Center Galesburg, Illinois  61401
Hopedale Medical Complex - Hospital Hopedale, Illinois  61747
Joliet Oncology-Hematology Associates Limited Joliet, Illinois  60435
Provena Saint Mary's Hospital Kankakee, Illinois  60901
Community Cancer Center Foundation Normal, Illinois  61761
Illinois CancerCare-Ottawa Clinic Ottawa, Illinois  61350
Ottawa Regional Hospital and Healthcare Center Ottawa, Illinois  61350
Pekin Cancer Treatment Center Pekin, Illinois  61554
Illinois Oncology Research Association CCOP Peoria, Illinois  61615
Illinois CancerCare-Peoria Peoria, Illinois  61615
Illinois Valley Hospital Peru, Illinois  61354
West Suburban Cancer Center River Forest, Illinois  60305
Saint Margaret's Hospital Spring Valley, Illinois  61362
Carle Clinic-Urbana Main Urbana, Illinois  61801
Saint Francis Hospital and Health Centers Beech Grove, Indiana  46107
Fort Wayne Medical Oncology and Hematology Inc - State Boulevard Fort Wayne, Indiana  46845
Saint Vincent Hospital and Health Services Indianapolis, Indiana  46260
Saint Anthony Memorial Health Center Michigan City, Indiana  46360
Reid Hospital and Health Care Services Richmond, Indiana  47374
McFarland Clinic Ames, Iowa  50010
Hematology Oncology Associates-Quad Cities Bettendorf, Iowa  52722
Cedar Rapids Oncology Association Cedar Rapids, Iowa  52403
Mercy Hospital Cedar Rapids, Iowa  52403
Medical Oncology and Hematology Associates-West Des Moines Clive, Iowa  50325
Genesis Medical Center - East Campus Davenport, Iowa  52803
Iowa Oncology Research Association CCOP Des Moines, Iowa  50309
Mercy Capitol Des Moines, Iowa  50307
Mercy Medical Center - Des Moines Des Moines, Iowa  50314
Medical Oncology and Hematology Associates-Des Moines Des Moines, Iowa  50309
Mercy Medical Center - North Iowa Mason City, Iowa  50401
Mercy Medical Center-Sioux City Sioux City, Iowa  51104
Saint Luke's Regional Medical Center Sioux City, Iowa  51104
Covenant Medical Center Waterloo, Iowa  50702
Cancer Center of Kansas - El Dorado El Dorado, Kansas  67042
Cancer Center of Kansas-Kingman Kingman, Kansas  67068
Cancer Center of Kansas - Parsons Parsons, Kansas  67357
Cancer Center of Kansas - Pratt Pratt, Kansas  67124
Cancer Center of Kansas-Wichita Medical Arts Tower Wichita, Kansas  67208
Cancer Center of Kansas - Main Office Wichita, Kansas  67214
Ochsner Clinic Foundation-Baton Rouge Baton Rouge, Louisiana  70809
Ochsner Clinic CCOP New Orleans, Louisiana  70121
Holy Family Hospital Methuen, Massachusetts  01844
North Shore Medical Center Cancer Center Peabody, Massachusetts  01960
Hickman Cancer Center Adrian, Michigan  49221
Michigan Cancer Research Consortium Community Clinical Oncology Program Ann Arbor, Michigan  48106
Oakwood Hospital Dearborn, Michigan  48123
Saint John Hospital and Medical Center Detroit, Michigan  48236
Green Bay Oncology - Escanaba Escanaba, Michigan  49431
Grand Rapids Clinical Oncology Program Grand Rapids, Michigan  49503
Saint Mary's Health Care Grand Rapids, Michigan  49503
Spectrum Health at Butterworth Campus Grand Rapids, Michigan  49503
Green Bay Oncology - Iron Mountain Iron Mountain, Michigan  49801
Allegiance Health Jackson, Michigan  49201
Sparrow Hospital Lansing, Michigan  48912
Saint Mary Mercy Hospital Livonia, Michigan  48154
Mid-Michigan Medical Center - Midland Midland, Michigan  48670
Mercy Memorial Hospital Monroe, Michigan  48162
Mercy Health Partners-Mercy Campus Muskegon, Michigan  49443
Northern Michigan Regional Hospital Petoskey, Michigan  49770
Saint Joseph Mercy Oakland Pontiac, Michigan  48341-2985
Saint Joseph Mercy Port Huron Port Huron, Michigan  48060
Saint Mary's of Michigan Saginaw, Michigan  48601
Lakeland Hospital St. Joseph, Michigan  49085
Saint John Macomb-Oakland Hospital Warren, Michigan  48093
Medini, Eitan MD (UIA Investigator) Alexandria, Minnesota  56308
Miller-Dwan Hospital Duluth, Minnesota  55805
Etzell, Paul S MD (UIA Investigator) Fergus Falls, Minnesota  56537
Swenson, Wade II, MD (UIA Investigator) Fergus Falls, Minnesota  56537
Unity Hospital Fridley, Minnesota  55432
Immanuel-Saint Joseph Hospital-Mayo Health System Mankato, Minnesota  56002
Saint John's Hospital - Healtheast Maplewood, Minnesota  55109
Minnesota Oncology Hematology PA-Maplewood Maplewood, Minnesota  55109
North Memorial Medical Health Center Robbinsdale, Minnesota  55422
Saint Cloud Hospital Saint Cloud, Minnesota  56303
Park Nicollet Clinic - Saint Louis Park Saint Louis Park, Minnesota  55416
Minnesota Oncology and Hematology PA-Woodbury Woodbury, Minnesota  55125
Saint Luke's Hospital of Kansas City Kansas City, Missouri  64111
Saint Joseph Health Center Kansas City, Missouri  64114
Truman Medical Center Kansas City, Missouri  64108
Missouri Baptist Medical Center Saint Louis, Missouri  63131
Ozark Health Ventures LLC dba Cancer Research for The Ozarks Springfield Springfield, Missouri  65802
Saint John's Hospital Springfield, Missouri  65804
Cox Medical Center Springfield, Missouri  65807
Hematology-Oncology Centers of the Northern Rockies PC Billings, Montana  59101
Saint Vincent Healthcare Billings, Montana  59101
Billings Clinic Billings, Montana  59107-7000
Saint James Community Hospital and Cancer Treatment Center Butte, Montana  59701
Benefis Healthcare- Sletten Cancer Institute Great Falls, Montana  59405
Berdeaux, Donald MD (UIA Investigator) Great Falls, Montana  59405
Saint Peter's Community Hospital Helena, Montana  59601
Glacier Oncology PLLC Kalispell, Montana  59901
Community Medical Hospital Missoula, Montana  59801
Saint Patrick Hospital - Community Hospital Missoula, Montana  59802
Good Samaritan Hospital Kearney, Nebraska  68847
Lincoln Medical Education Foundation Cancer Resource Center Lincoln, Nebraska  68510
Missouri Valley Cancer Consortium CCOP Omaha, Nebraska  68106
Nevada Cancer Research Foundation CCOP Las Vegas, Nevada  89106
Exeter Hospital Exeter, New Hampshire  03833
New Hampshire Oncology Hematology Associates Hooksett, New Hampshire  03106
Cheshire Medical Center-Dartmouth-Hitchcock Keene Keene, New Hampshire  03431
LRGHealthcare-Lakes Region General Hospital Laconia, New Hampshire  03246
Cooper Hospital University Medical Center Camden, New Jersey  08103
Hunterdon Medical Center Flemington, New Jersey  08822
Sparta Cancer Treatment Center Sparta, New Jersey  07871
South Jersey Healthcare Vineland, New Jersey  08360
Adirondack Cancer Center Glens Falls, New York  12801
State University of New York Upstate Medical University Syracuse, New York  13210
Faxton-Saint Luke's Healthcare Utica, New York  13502
Mission Hospitals Inc Asheville, North Carolina  28801
Alamance Regional Medical Center Burlington, North Carolina  27216
Wayne Memorial Hospital Goldsboro, North Carolina  27534
Margaret R Pardee Memorial Hospital Hendersonville, North Carolina  28791
Kinston Medical Specialists PA Kinston, North Carolina  28501
Marion L Shepard Cancer Center Washington, North Carolina  27889
Saint Alexius Medical Center Bismarck, North Dakota  58501
Summa Barberton Hospital Barberton, Ohio  44203
Aultman Health Foundation Canton, Ohio  44710
Doctors Hospital Columbus, Ohio  43228
Grant Medical Center Columbus, Ohio  43215
Mount Carmel Health Center West Columbus, Ohio  43222
Good Samaritan Hospital - Dayton Dayton, Ohio  45406
Dayton CCOP Dayton, Ohio  45429
Samaritan North Health Center Dayton, Ohio  45415
Hematology Oncology Center Incorporated Elyria, Ohio  44035
Blanchard Valley Hospital Findlay, Ohio  45840
Atrium Medical Center-Middletown Regional Hospital Franklin, Ohio  45005-1066
Kettering Medical Center Kettering, Ohio  45429
Saint Rita's Medical Center Lima, Ohio  45801
Marietta Memorial Hospital Marietta, Ohio  45750
Toledo Radiation Oncology at Northwest Ohio Onocolgy Center Maumee, Ohio  43537
Saint Charles Hospital Oregon, Ohio  43616
North Coast Cancer Care Sandusky, Ohio  44870
Toledo Community Hospital Oncology Program CCOP Toledo, Ohio  43617
Mercy Cancer Center at Saint Anne Mercy Hospital Toledo, Ohio  43623
University of Toledo Toledo, Ohio  43614
Saint Vincent Mercy Medical Center Toledo, Ohio  43608
Upper Valley Medical Center Troy, Ohio  45373
Saint Ann's Hospital Westerville, Ohio  43081
Wright-Patterson Medical Center Wright-Patterson Afb, Ohio  45433-5529
Genesis HealthCare System Zanesville, Ohio  43701
Natalie W Bryant Cancer Center Tulsa, Oklahoma  74136
Legacy Good Samaritan Hospital and Medical Center Portland, Oregon  97210
Providence Saint Vincent Medical Center Portland, Oregon  97225
Columbia River Oncology Program Portland, Oregon  97225
Ephrata Cancer Center Ephrata, Pennsylvania  17522
Riddle Hospital Media, Pennsylvania  19063
Pottstown Memorial Medical Center Pottstown, Pennsylvania  19464
Saint Joseph Medical Center Reading, Pennsylvania  19605
Hematology and Oncology Associates of North East Pennsylvania Scranton, Pennsylvania  18508
Scranton Hematology Oncology Scranton, Pennsylvania  18510
Mercy Hospital Scranton, Pennsylvania  18501
Associates In Hematology Oncology PC-Upland Upland, Pennsylvania  19013
Geisinger Wyoming Valley Wilkes-Barre, Pennsylvania  18711
Mainline Health CCOP Wynnewood, Pennsylvania  19096
AnMed Health Hospital Anderson, South Carolina  29621
Greenville CCOP Greenville, South Carolina  29615
Greenville Memorial Hospital Greenville, South Carolina  29605
Upstate Carolina CCOP Spartanburg, South Carolina  29303
Conklin Regional Cancer Center Aberdeen, South Dakota  57401
Sanford Cancer Center-Oncology Clinic Sioux Falls, South Dakota  57104
Fredericksburg Oncology Inc Fredericksburg, Virginia  22401
Saint Francis Hospital Federal Way, Washington  98003
Providence - Saint Peter Hospital Olympia, Washington  98506-5166
Good Samaritan Community Hospital Puyallup, Washington  98372
Northwest CCOP Tacoma, Washington  98405
Multicare Health System Tacoma, Washington  98415
Saint Clare Hospital Tacoma, Washington  98499
Saint Joseph Medical Center Tacoma, Washington  98405
Edwards Comprehensive Cancer Center Huntington, West Virginia  25701
Saint Vincent Hospital Green Bay, Wisconsin  54301
Green Bay Oncology Limited at Saint Mary's Hospital Green Bay, Wisconsin  54303
Saint Mary's Hospital Green Bay, Wisconsin  54303
Green Bay Oncology at Saint Vincent Hospital Green Bay, Wisconsin  54301-3526
Aurora BayCare Medical Center Green Bay, Wisconsin  54311-6519
Dean Hematology and Oncology Clinic Madison, Wisconsin  53717
Vince Lombardi Cancer Clinic-Marinette Marinette, Wisconsin  54143
Bay Area Medical Center Marinette, Wisconsin  54143
Marshfield Clinic-Minocqua Center Minocqua, Wisconsin  54548
Oconomowoc Memorial Hospital-ProHealth Care Inc Oconomowoc, Wisconsin  53066-3896
Green Bay Oncology - Oconto Falls Oconto Falls, Wisconsin  54154
Marshfield Clinic at James Beck Cancer Center Rhinelander, Wisconsin  54501
Marshfield Clinic-Rice Lake Center Rice Lake, Wisconsin  54868
Green Bay Oncology - Sturgeon Bay Sturgeon Bay, Wisconsin  54235
Women and Infants Hospital Providence, Rhode Island  02905
Lynn Regional Cancer Center - West Boca Raton, Florida  33428
Jupiter Medical Center Jupiter, Florida  33458
Gainesville Hematology Oncology Associates Gainesville, Florida  32605
University of Illinois Chicago, Illinois  60612
Elkhart Clinic Elkhart, Indiana  46515
Marin General Hospital Greenbrae, California  94904
Memorial Healthcare System - Joe DiMaggio Children's Hospital Hollywood, Florida  33021
Mount Sinai Medical Center CCOP Miami Beach, Florida  33140
Northeast Georgia Cancer Care LLC Athens, Georgia  30607
Harbin Clinic Medical Oncology and Clinical Research Rome, Georgia  30165
Illinois CancerCare-Bloomington Bloomington%, Illinois  61701
Illinois CancerCare-Canton Canton, Illinois  61520
Illinois CancerCare-Carthage Carthage, Illinois  62321
Illinois CancerCare-Eureka Eureka, Illinois  61530
Illinois CancerCare-Cottage Galesburg, Illinois  61401
Illinois CancerCare-Havana Havana, Illinois  62644
Illinois CancerCare-Kewanee Clinic Kewanee, Illinois  61443
Illinois CancerCare-Macomb Macomb, Illinois  61455
Illinois CancerCare-Monmouth Monmouth, Illinois  61462
Illinois CancerCare-Community Cancer Center Normal, Illinois  61761
Illinois CancerCare-Pekin Pekin, Illinois  61603
Illinois CancerCare-Peru Peru, Illinois  61354
Illinois CancerCare-Princeton Princeton, Illinois  61356
Illinois CancerCare-Spring Valley Spring Valley, Illinois  61362
Michiana Hematology Oncology PC-Elkhart Elkhart, Indiana  46514
Michiana Hematology Oncology PC-Plymouth Plymouth, Indiana  46563
Michiana Hematology Oncology PC-South Bend South Bend, Indiana  46601
Michiana Hematology Oncology-PC Westville Westville, Indiana  46391
Cancer Center of Kansas-Liberal Liberal, Kansas  67901
The Memorial Hospital at Easton Easton, Maryland  21601
Michiana Hematology Oncology PC-Niles Niles, Michigan  49120
Central Care Cancer Center-Carrie J Babb Cancer Center Bolivar, Missouri  65613
Skaggs Cancer Center Branson, Missouri  65616
University of Missouri - Ellis Fischel Columbia, Missouri  65203
Hackensack University Medical CCOP Hackensack, New Jersey  07601
UMDNJ - New Jersey Medical School Newark, New Jersey  07103
AtlantiCare Regional Medical Center -Main Campus Pomona, New Jersey  08240
Moses Cone Health System-Regional Cancer Center Greensboro, North Carolina  27403
Maria Parham Hospital Henderson, North Carolina  27536
Rex Cancer Center Raleigh, North Carolina  27607
Duke Raleigh Hospital Raleigh, North Carolina  27609
Annie Penn Memorial Hospital Reidsville, North Carolina  27320
North Coast Cancer Care-Clyde Clyde, Ohio  43410
Community Health Partners Regional Medical Center Elyria, Ohio  44035
Oncology Hematology Associates of Northern Pennsylvania Dubois, Pennsylvania  15801
Cancer Centers of the Carolinas - Faris Greenville, South Carolina  29605
Cancer Centers of the Carolinas-Greer Radiation Oncology Greer, South Carolina  29650
Cancer Centers of the Carolinas-Greer Medical Oncology Greer, South Carolina  29650
University of Tennessee - Knoxville Knoxville, Tennessee  37920
Nashville Oncology Associates PC Nashville, Tennessee  37203
Virginia Oncology Associates-Hampton Hampton, Virginia  23666
Marshfield Clinic-Chippewa Center Chippewa Falls, Wisconsin  54729
Holy Family Memorial Hospital Manitowoc, Wisconsin  54221
Aurora Advanced Healthcare Inc-Mequon Mequon, Wisconsin  53092
Vince Lombardi Cancer Clinic-Sheboygan Sheboygan, Wisconsin  53081
Marshfield Clinic Cancer Care at Saint Michael's Hospital Stevens Point, Wisconsin  54481
Aurora Medical Center in Summit Summit, Wisconsin  53066
Vince Lombardi Cancer Clinic Two Rivers, Wisconsin  54241
Monter Cancer Center Lake Success, New York  11042
FirstHealth of the Carolinas-Moore Regional Hosiptal Pinehurst, North Carolina  28374
Cancer Centers of Southwest Oklahoma Research Lawton, Oklahoma  
Kaiser Anaheim Medical Center Anaheim, California  92807
Kaiser Permanente-Deer Valley Medical Center Antioch, California  94531
Kaiser Permanente Medical Group - Baldwin Park Baldwin Park, California  91706
Kaiser Foundation Hospital Bellflower, California  90706
Kaiser Permanente Hospital Fontana, California  92335
Kaiser Permanente - Harbor City Harbor City, California  90710
Kaiser Permanente-West Los Angeles Los Angeles, California  90034
Kaiser Permanente - Panorama City Panorama City, California  91402
Palchak David MD Pismo Beach, California  93449
Salinas Valley Memorial Salinas, California  93901
Kaiser Permanente at San Diego San Diego, California  92120
Kaiser Permanente Health Care San Marcos, California  92069
Kaiser Permanente Medical Center-Vacaville Vacaville, California  95688
Kaiser Permanente-Rock Creek Lafayette, Colorado  80026
Kaiser Permanente Moanalua Medical Center Honolulu, Hawaii  96819
Wilcox Memorial Hospital and Kauai Medical Clinic Lihue, Hawaii  96766-1099
OSF Saint Francis Medical Center Radiation Oncology Service at the Central Illinois Comprehensive CC Peoria, Illinois  61615-7827
Saint Luke's South Hospital Overland Park, Kansas  66213
Kansas City CCOP Prairie Village, Kansas  66208
Doctors Carrol, Sheth, Raghavan Louisville, Kentucky  40215
Hematology and Oncology Clinic Baton Rouge, Louisiana  70809
Ochsner North Shore Medical Center Covington, Louisiana  70433
Capital Region Medical Center-Goldschmidt Cancer Center Jefferson City, Missouri  65109
Heartland Hematology and Oncology Associates Incorporated Kansas City, Missouri  64118
Saint Joseph Oncology Inc Saint Joseph, Missouri  64507
Comprehensive Cancer Care PC Saint Louis, Missouri  63141
Coney Island Hospital Brooklyn, New York  11235
Southern Ohio Medical Center Portsmouth, Ohio  45662
Cancer Care Associates-Mercy Oklahoma City, Oklahoma  73120
Asante Health System Medford, Oregon  97504
Rogue Valley Medical Center Medford, Oregon  97504
Saint Francis Hospital Greenville, South Carolina  29601
Hematology Oncology Associates of Fredericksburg Inc Fredericksburg, Virginia  22401
Memorial Hospital Of Martinsville Martinsville, Virginia  24115
Gundersen Lutheran La Crosse, Wisconsin  54601
Saint Nicholas Hospital Madison, Wisconsin  53715
Columbia Saint Mary's Water Tower Medical Commons Milwaukee, Wisconsin  53211
Sparks Regional Medical Center Fort Smith, Arkansas  72901
Lexington Medical Center West Columbia, South Carolina  29169
San Francisco General Hospital San Francisco, California  94110
Kaiser Permanente-Franklin Denver, Colorado  80205
Beaufort Memorial Hospital Beaufort, South Carolina  29902
Siouxland Hematology Oncology Associates Sioux City, Iowa  51101
Walter Reed National Military Medical Center Bethesda, Maryland  20889
Kaiser Permanente-Mission San Diego, California  92108
Norris Cotton Cancer Center-Manchester Manchester, New Hampshire  03104
Dublin Hematology Oncology Care PC Dublin, Georgia  31021
IU Health Arnett Lafayette, Indiana  
Georgia Health Sciences University Augusta, Georgia  30912
Alta Bates Summit Medical Center-Herrick Campus Berkeley, California  94704
Carle Foundation - Carle Cancer Center Urbana, Illinois  61801
Michiana Hematology Oncology PC-Mishawaka Mishawaka, Indiana  46545-1470
Oncology Associates at Mercy Medical Center Cedar Rapids, Iowa  52403
Marie Yeager Cancer Center Saint Joseph, Michigan  49085
The Dana-Farber Cancer Institute at Londonderry Londonderry, New Hampshire  03053
Hematology Oncology Associates of Central New York PC East Syracuse, New York  13057
Sanford Clinic North-Fargo Fargo, North Dakota  58102
Sanford Medical Center-Fargo Fargo, North Dakota  58122
Summa Akron City Hospital Akron, Ohio  44304
Roy and Patricia Disney Family Cancer Center Burbank, California  91505
Indiana University Health Goshen Center For Cancer Care Goshen, Indiana  46526
The Toledo Hospital/Toledo Children's Hospital Toledo, Ohio  43606
Sanford USD Medical Center - Sioux Falls Sioux Falls, South Dakota  57117-5134
Providence Sacred Heart Medical Center and Children's Hospital Spokane, Washington  99204
North Shore-LIJ Health System CCOP Manhasset, New York  11030
Genesys Regional Medical Center-West Flint Campus Flint, Michigan  48532
Sanford Clinic North-Bemidgi Bemidji, Minnesota  56601
Essentia Health Duluth Clinic CCOP Duluth, Minnesota  55805
Essentia Health Saint Mary's Medical Center Duluth, Minnesota  55805
Sanford Bismarck Medical Center Bismarck, North Dakota  58501
Toledo Clinic Cancer Centers-Oregon Oregon, Ohio  43616
Geisinger Medical Center-Cancer Center Hazelton Hazleton, Pennsylvania  18201
Community Howard Regional Health Kokomo, Indiana  46904
Indiana University Health La Porte Hospital La Porte, Indiana  46350
Saint Joseph Regional Medical Center-Mishawaka Mishawaka, Indiana  46545-1470
Via Christi Hospital-Pittsburg Pittsburg, Kansas  66762
Essentia Health Cancer Center-South University Clinic Fargo, North Dakota  58103
Aurora Cancer Care-Burlington Burlington, Wisconsin  53105
Aurora Cancer Care-Franklin Franklin, Wisconsin  53132
Aurora Cancer Care-Glendale Glendale, Wisconsin  53212
Aurora Cancer Care-Kenosha South Kenosha, Wisconsin  53142
Aurora Cancer Care-Milwaukee South Milwaukee, Wisconsin  53215
Aurora Cancer Care-Racine Racine, Wisconsin  53406-5661
Aurora Cancer Care-Waukesha Waukesha, Wisconsin  53188
Aurora Cancer Care-Milwaukee West Wauwatosa, Wisconsin  53226
Christiana Care Health System-Christiana Hospital Newark, Delaware  19718
Bronson Battle Creek Battle Creek, Michigan  49017
Riverview Medical Center/Booker Cancer Center Red Bank, New Jersey  07701
Springfield Regional Medical Center Springfield, Ohio  45505
NEA Baptist Memorial Hospital Jonesboro, Arkansas  72401
Marin Cancer Care Inc Greenbrae, California  94904
Lake Region Healthcare Corporation-Cancer Care Fergus Falls, Minnesota  56537
Toledo Clinic Cancer Centers-Bowling Green Bowling Green, Ohio  43402
Toledo Clinic Cancer Centers-Maumee Maumee, Ohio  43537-1839
Toledo Clinic Cancer Centers-Toledo Toledo, Ohio  43623
Guthrie Clinic-Robert Packer Hospital Sayre, Pennsylvania  18840
Self Regional Healthcare Greenwood, South Carolina  29646
Providence Holy Family Hospital Spokane, Washington  99208
PeaceHealth Southwest Medical Center Vancouver, Washington  98664
Aurora Cancer Care-Southern Lakes Elkhorn, Wisconsin  53121
Mayo Clinic Health System-Franciscan Healthcare La Crosse, Wisconsin  54601
Halifax Health Medical Center-Centers for Oncology Daytona Beach, Florida  32114
Maine Center for Cancer Medicine and Blood Disorders-Scarborough Scarborough, Maine  04074
Ochsner Baptist Medical Center New Orleans, Louisiana  70115
Cancer Care Associates-Norman Norman, Oklahoma  73071
Mercy Physicians of Oklahoma-Lakeside Oklahoma City, Oklahoma  73120
Providence Willamette Falls Medical Center Oregon City, Oregon  97045
Medical Oncology Hematology Associates of Northern Virginia Limited Fairfax, Virginia  22031
Nash General Hospital Rocky Mount, North Carolina  27804
Associated Medical Specialists PA dba Coastal Cancer Center Myrtle Beach, South Carolina  29572
D N Greenwald Center Mukwonago, Wisconsin  53149