Influence of Matrix Metalloproteinase on Brain Arteriovenous Malformation Hemorrhage
- Doses will be randomized by the Pharmacy Department at UCSF for Doxycycline 100 mg/BID
and Placebo BID. These will be prepared in blister-packs.
- Depending on enrollment/surgery date, patients will take medication either one to two
weeks before surgery. Patients will be assigned to a treatment group according to a
- Each patient will be initially provided with a 1 or 2-week supply of drug in blister
packs. The patient will take the final dose of study drug on the morning of surgery.
Baseline labs will be obtained and then again at time of surgery along with a piece of
Allocation: Randomized, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Prevention
Our primary aim is to perform a pilot study to document the effect of doxycycline therapy to decrease MMP expression in the vascular malformation tissue.
1 to 2-week pre-operative
Chanhung Lee, MD
University of California, San Francisco
United States: Institutional Review Board
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