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Evaluation the Possible Influence of Transcatheter Arterial Chemoembolization on Hepatitis B Viral Replication

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Hepatocellular Carcinoma, Hepatitis B Virus

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Trial Information

Evaluation the Possible Influence of Transcatheter Arterial Chemoembolization on Hepatitis B Viral Replication

Hepatocellular carcinoma (HCC) is the most common malignant tumor of the liver. Chronic
hepatitis B infection is the common etiology for the development of HCC. Transcatheter
arterial chemoembolization (TACE) is the traditional method for the palliative management of
patients with HCC. Few previous studies had demonstrated that the serum level of anticancer
drug from patients treated by TACE was similar to those treated by systemic chemotherapy.
Since systemic chemotherapy may have the possibility to influence patient's general defense
ability, hepatitis B virus may reactivate after chemotherapy. There is no study to
investigate the possibility of TACE in the reactivation of hepatitis B virus. This project
will collect 20 patients with HCC caused by hepatitis B who are planned to be treated by
TACE. Quantitative determination of viral load in blood will be performed before TACE, the
first and the third month after TACE to investigate the influence of TACE on hepatitis B
virus replication. This study will not influence the doctor's decision in the management of
HCC and the procedure of TACE. The serum used for HBV DNA examination is concomitantly
obtained during regular blood sampling for TACE preparation and follow-up of patient. The
amount of blood needed for each time HBV DNA examination is less than 10 ml.

Inclusion Criteria:

- patients with hepatocellular carcinoma caused by hepatitis B virus without antiviral
drug treatment and patients will be treated by transcatheter arterial

Exclusion Criteria:

- patients already received antiviral drug management

Type of Study:


Study Design:

Observational Model: Case Control, Time Perspective: Prospective

Outcome Measure:

HBV viral load

Outcome Time Frame:

3 months

Safety Issue:


Principal Investigator

zu y lin, MD, Ms

Investigator Role:

Principal Investigator

Investigator Affiliation:

Kaohsiung Medical University


Taiwan: Department of Health

Study ID:




Start Date:

January 2008

Completion Date:

February 2009

Related Keywords:

  • Hepatocellular Carcinoma
  • Hepatitis B Virus
  • hepatocellular carcinoma
  • hepatitis B virus
  • transcatheter arterial chemoembolization
  • Carcinoma
  • Hepatitis
  • Hepatitis A
  • Hepatitis B
  • Carcinoma, Hepatocellular