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18 Years
Open (Enrolling)
Radiation Injury, Brain Tumor

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Trial Information

Inclusion Criteria:

- Patients previously treated with radiation therapy (including radiosurgery), with or
without previous surgery or chemotherapy, with a new contrast enhancing lesion(s)
with the size of 1 cm or more on conventional brain MRI examination are eligible

- Patients must have a previously histological confirmed brain tumor

- Patients must be 18 years of age or older

- Patients must sign a study-specific consent form approved by the Institutional Review
Board of the University of Michigan indicating prior to study entry

Exclusion Criteria:

- Pregnant woman

- For the purpose of this radiological study and in collecting data from the patient
but not from receiving the MR Spectroscopy if it is clinically indicated.

- Patients unable to undergo MRI imaging because of non-compatible devices such as
cardiac pacemakers, other implanted electronic devices, or foreign body in the eye

- Also patients with metallic prostheses, or ferromagnetic prostheses (e.g. pins in
artificial joints and surgical pins/clips in the face or skull region), or patients
with braces since these devices may cause metal artifacts which may obscure the
images and result in artifacts on the MR spectroscopy.

- Prisoners

Type of Study:


Study Design:

Time Perspective: Prospective

Outcome Measure:

Magnetic resonance imaging of treated brain tumors

Outcome Description:

The purpose of this study is to determine if certain MRI imaging sequences are more helpful to the physicians in determining if the tumor has come back or if it is radiation injury

Outcome Time Frame:

6mth. and 1 year follow-up

Safety Issue:


Principal Investigator

Pia M Sundgren, MD, Ph.D

Investigator Role:

Principal Investigator

Investigator Affiliation:

University of Michigan Hospital


United States: Institutional Review Board

Study ID:




Start Date:

September 2008

Completion Date:

September 2014

Related Keywords:

  • Radiation Injury
  • Brain Tumor
  • recurrent tumor
  • Brain Neoplasms
  • Radiation Injuries



University of MichiganAnn Arbor, Michigan  48109-0624