A Radiopharmacokinetic and Radiodosimetric Phase I Imaging Study of 18F-FAZA
A Phase I Radiopharmacokinetic and Radiodosimetric study of 18F-FAZA. Prior to treatment,
subjects will receive a single injection of 18F-FAZA. Subjects will undergo a series of 5-5
PET scans, and will have 8-13 blood samples and 2 urine samples taken at specified time
points over a 4.5-5.5 hour period. 18F-FAZA PET images will be reviewed to develop a
dynamic uptake model, and blood and urine samples will be analyzed for unchanged 18F-FAZA
and its metabolites.
Observational Model: Cohort, Time Perspective: Prospective
To Collect imaging-based data for radiopharmacokinetic and radiodosimetric analyses.
Alexander J. B. McEwan, MD, FRCPC
Alberta Health Services
Canada: Health Canada