Inclusion Criteria:

- Histologically- or cytologically- confirmed metastatic breast adenocarcinoma

- No HER2 overexpression or gene amplification

- At least one previous chemotherapy regimen for metastatic breast cancer

- Age ≥18 years

- Performance status (WHO) 0-2

- Life expectancy of at least 12 weeks

- Measurable disease as defined by at least 1 bidimensionally measurable lesion ≥ 20 X
10 mm

- Performance status (WHO) 0-2

- Adequate liver function (serum bilirubin <1.5 times the upper normal limit, AST and
ALT <2.5 times the upper normal limit in the absence of demonstrable liver
metastases, or <5 times the upper normal limit in the presence of liver metastases),
adequate renal function (serum creatinine <1.5 times the upper normal limit) and bone
marrow ≥ 1,500/mm3, PLT ≥ 100,000/mm3, Hgb ≥ 9 g/dL) function

- Written informed consent

Exclusion Criteria:

- Pregnant or lactating women

- Progressive brain metastases according to clinical or radiological criteria

- Brain metastases without prior radiation therapy

- Radiation therapy within the previous 4 weeks

- Previous radiation therapy to the only measurable lesion

- Proteinuria ≥ 500 mgr of protein daily

- Uncontrolled hypertension

- Documented hemorrhagic diathesis or coagulation disorder

- Cardiovascular disease (class II-IV NYHA congestive heart failure, myocardial
infarction within the previous 4 months, unstable angina, LVEF < normal, ventricular
arrhythmia, uncontrolled hypertension)

- Thrombotic event within the previous 6 months

- Concurrent use of aspirin > 325 mgr daily, low molecular weight heparin in
therapeutic dose, warfarin or acenocoumarol, non-steroid anti-inflammatory agents

- Major surgical procedure within the previous 4 weeks

- Presence of nonhealing wound or fracture

- Peripheral neuropathy > grade 2 according to the NCI CTCAE (version 3.0)

- Any sustained chronic toxicity > grade 2 according to the NCI CTCAE (version 3.0)

- Uncontrolled infection

- Any serious, uncontrolled comorbidity on the investigator's judgment

- Other cancer within the previous 5 years, except non-melanoma skin cancer and in situ
cervical cancer

- Serious psychiatric illness