Inclusion Criteria:

1. Patients must have Advanced or recurrent esophageal cancer, and treatment has failed,
or in the situation where effective therapy is not available, or has been refused due
to severe adverse effects of chemotherapy

2. WHO performance status of 0 to 2

3. Age ≥ 20 years, ≤80 years

4. The patient does not need to have a measurable disease, but must have a disease that
an effect judgment is possible

5. Passing from previous treatment more than two weeks. Passing from radiation therapy
more than four weeks.

6. Expected survival of at least 3 months

7. WBC≥ 1,500/mm³ WBC≤ 15,000/mm³ Platelet count ≥ 50,000/mm³ Total bilirubin ≤ 3 x the
institutional normal upper limits AST, ALT ≤ 3 x the institutional normal upper
limits Creatinine ≤ 3 x the institutional normal upper limits

8. Patients must be HLA-A2402

9. Able and willing to give valid written informed consent

Exclusion Criteria:

1. Pregnancy, Promise of the pregnancy, Hope of the pregnancy, Breastfeeding

2. Serious infections requiring antibiotics

3. Concurrent treatment with steroids or immunosuppressing agent

4. Disease to the central nervous system

5. Decision of unsuitableness by principal investigator or physician-in-charge