Inclusion Criteria:

- Patients with non-small cell or small cell lung cancer or mesothelioma candidate for
radical treatment

- either by surgical resection with or without perioperative chemotherapy

- or by thoracic radiotherapy with or without chemotherapy

- Between 18 and 80 years of age

- Written informed consent

Supplementary criteria for PART II:

- Treatment for their cancer considered radical

- either by surgical resection with or without perioperative chemotherapy

- or by thoracic radiotherapy with or without chemotherapy

- having less than 70% of the predicted normal value of the Quadriceps Force (QF) or a
decrease of more than 10% predicted value of the QF between the baseline and
post-radical therapy measurement of QF

- Post treatment assessment maximum 14 days after radical treatment or between 6th and
8th week after radical treatment if the latter consists only of surgical resection

Exclusion Criteria:

Patients presenting with one or more of the following will be excluded:

- Severe anemia (Hb below 8 g/dl)

- Fever (> 38°C)

- Cachexia (loss of more than 35% of premorbid weight)

- Severe cardiac, neurological and orthopedic co-morbidity interfering with exercise
training.

- A pacemaker, hip, knee of shoulder prosthesis or recently introduced spirals, metal
pens, bolts or plates

- Uncontrolled diabetes, epilepsy or migraine

- Uncontrolled vertebral diseases (osteoporotic or metastatic fractures, acute hernia,
discopathy, spondylitis)

- Open wounds