microRNA Expression in Renal Cell Carcinoma
Due to the lack of specific indicators for the early diagnosis of RCC, the RCC patients
often have distant metastasis when diagnosed and their five-year survival rate is much low.
Therefore, the biological markers of RCC are needed for early detection, early treatment and
improvement of the survival rate of RCC patients.
MiRNA and tumor are closely related. MiRNA can control the important cancer-related genes
and participate in the tumor cell proliferation, apoptosis, invasion and angiogenesis.
In this study, renal cell carcinoma(RCC) related miRNA and the target genes of related miRNA
will be examined,and the relationship between RCC related miRNA and the RCC pathological
types, TNM (tumor-nodes-metastasis) stages and prognosis will be analyzed. The purpose of
this study is to investigate the role of miRNA in the formation of RCC and look for the
biomarker of RCC.
Observational Model: Case-Only, Time Perspective: Cross-Sectional
Xueqing Yu, M.D. & Ph.D.
1st Affiliated Hospital, Sun Yat-Sen University
China: Food and Drug Administration