Trial Information

Free Soft Tissue Graft in Treatment of Oral Lichen Planus

Oral lesions in OLP are chronic ,rarely undergo spontaneous remission, are potentially
premalignant and are often a source of morbidity. recent study does not support that non
reticular OLP are more predisposed to malignant change. Moreover , immunosuppressive therapy
did not influence the risk for oral cancer. in general ,all treatment should be aimed at
eliminating precancerous lesions ,alleviating symptoms ,and potentially decreasing the risk
of malignant transformation. Although the cause of OLP is unknown , it is generally
considered to be an immunologically mediated process that microscopically resembles a
hypersensitivity reaction .it is characterized by an intense T cell infiltrate localized to
epithelium-connective tissue interface. the purpose of the study is to determined the
efficacy of free soft tissue graft in treatment of precancerous and symptomatic lesions of
OLP. so removal of the lesions up to submucosa will be done. the graft sliced from healthy
mucosa also up to submucosa . then graft will be sutured in position.

According to other authors, basal epithelial layers of the graft remain intact and
represent the focus of reepithelialization. new epithelial cell migrate over the basal
membrane and appear to guide it and by proliferation ,will generate new epithelium. so the
wound is re-epithelialized by proliferation of surrounding healthy epithelial cell,
therefore, not contaminated by modified antigens of the cell membrane that are theoretically
responsible for lymphocyte aggression so the healthy graft remains free of lesions and
appears clinically healthy.