Inclusion Criteria:

- You must have confirmed metastatic or advanced cancer that has not responded to
standard therapy or where standard therapy does not exist

- In Part C, patients must have a diagnosis of advanced or metastatic colorectal
adenocarcinoma or non-small cell lung cancer, and must have received at least 1 but
no more than three prior systemic therapy treatment regimens

- You must be over the age of 18 years old

- You must have a ECOG status performance of 0 or 1

- You must have good organ function

- You must be willing to have skin and/or tumor biopsies

Exclusion Criteria:

- You have had cancer treatment within 4 weeks prior to entering the study or you still
have bad side effects from previous therapies

- You have an active infection that requires treatment

- You are HIV positive or have a history of Hepatitis B or C