Inclusion Criteria:

- Subject was previously diagnosed with multiple myeloma bases on standard criteria
listed in protocol

- Patients must have relapsed or relapsed/refractory disease

- 18 years of age or older

- All necessary baseline studies for determining eligibility must be obtained within 21
days prior to enrollment

- ECOG Performance Status of 0 to 2

- Able to take aspirin (81 or 325mg) daily as prophylactic anticoagulation

- Prior thalidomide/lenalidomide therapy is allowed

- Able to take bactrim

- Female of childbearing potential must have a negative serum or urine pregnancy test

Exclusion Criteria:

- Renal insufficiency

- Concommitant therapy medications that include corticosteroids or other chemotherapy
that is or may be active against myeloma or therapy with chemotherapy within 2 weeks
prior to day 1. Nitrosoureas must be discontinued 6 weeks prior to day 1.
Concurrent radiation therapy is not permitted.

- Subjects with evidence of mucosal or internal bleeding and/or platelet refractory

- Subjects with poorly controlled diabetes mellitus

- Subjects with an ANC < 10-00 cells/mm3

- Subjects with a hemoglobin < 8.0 g/Dl

- AST (SGOT and ALT (SGPT) greater or equal to 2x ULN

- Prior therapy with RAD001

- Known hypersensitivity to thalidomide or lenalidomide

- Any condition, including laboratory abnormalities, that in the opinion of the
Investigator, places the subject at unacceptable risk if he/she were to participate
in the study

- Clinically relevant active infection or serious co-morbid medical conditions such as
recent thromboembolic disease are ineligible if occurred less than 2 weeks prior to
enrollment or clinically unstable

- Chronic obstructive or chronic restrictive pulmonary disease, difficult to control
diabetes, upper gastrointestinal ulceration, and cirrhosis

- Prior malignancy (within the last 3 years) except for adequately treated basal cell
or squamous cell skin cancer, in situ cervical cancer, in situ breast cancer, in situ
prostate cancer or other cancer for which the subject has been disease-free for at
least 3 years

- Pregnant or breast-feeding females

- Prior treatment with any investigational drug within preceding 4 weeks

- Major surgery, and or radiation with 2 weeks of study initiation

- Uncontrolled leptomeningeal disease

- Prior treatment with other mTOR inhibitors

- The use of G-CSF is not permitted to render the patient eligible fot the study

- POEMS syndrome

- Known HIV infection

- Known active Hepatitis B or C infection

- Myocardial infarction within 6 months prior to enrollment or has NYHA Class III or IV
heart failure, uncontrolled ventricular arrhythmias, or electrocardiographic evidence
of acute ischemia or active conduction system abnormalities

- Impairment of gastrointestinal function or gastrointestinal disease that may
significantly alter the absorption of RAD001

- Patients with active, bleeding diathesis or on oral anti-vitamin K medication