CCCWFU 99108 - Effect of Exercise Training in Patients Receiving Anthracycline Drugs - A Pilot Study
- To determine if patients with cancer can exercise safely and routinely, under
supervision, while receiving anthracycline chemotherapy.
- To determine the magnitude of the change in the peak ventilatory oxygen uptake (VO2)
before and after completion of anthracycline chemotherapy with concurrent exercise
versus without exercise in patients with cancer.
OUTLINE: Patients are randomized to 1 of 2 intervention arms.
- Arm I (exercise): Patients undergo supervised aerobic exercise (walk or bicycle) 3 days
a week concurrently with standard anthracycline-based chemotherapy for approximately
- Arm II (non-exercise): Patients receive standard anthracycline-based chemotherapy for
approximately 18-24 weeks.
Patients undergo peak ventilatory oxygen uptake (VO_2) by exercise bike test with gas
exchange analysis at baseline and at 2 weeks after completion of anthracycline-based
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Supportive Care
Percentage of patients enrolling in the study
Gretchen Wells, MD, PhD
Comprehensive Cancer Center of Wake Forest University
United States: Institutional Review Board
|Wake Forest University Comprehensive Cancer Center||Winston-Salem, North Carolina 27157-1096|