Inclusion Criteria:

- Brest adenocarcinoma stages II/III

- Female

- Informed consent signed

- HER2 negative

- Age>18 years old

- ECOG < 1

- Proper organic function regarding the following criteria:

1. ANC > 2,0 x 109L, platelets > 100 x 109L and hemoglobin > 10g/dL (transfusion is
allowed)

2. Hepatic Function:

i.Bilirubin < 1,5 x UNL ii.AST ,ALT < 2,5 x UNL iii.Alkaline phosphatase < 5 UNL
iv.Patients with AST and /or ALT > 1.5 x UNL and alkaline phosphatase > 2.5 x UNL
will not be selected for the study c.Renal function: creatinine < 1,25 x UNL, or
creatinine clearance > 60 mL/min d.Normal Cardiac function, confirmed with FEVI >50%
and electrocardiogram.

- Patients should be available for treatment and follow up and must be treated in
investigator or co-investigator site

- Negative pregnancy test(performed 7 days before treatment)

Exclusion Criteria:

- Previous treatment for breast cancer (CT, RT, IT, HT)

- Stages IIIb, IIIc or IV or invasive bilateral breast cancer

- Previous neoplasias treated with Anthracyclines or Taxanes (Paclitaxel or Docetaxel)

- Pregnant or breastfeeding females

- Neurotoxicity Grade 2

- FEV≤50% or any cardiac disease in which anthracyclines are contraindicated

- Other severe diseases regarding investigator criteria

- Any neurological or psychiatric pathology

- Previous neoplasia different from breast cancer except:

1. skin cancer(no melanoma)

2. In situ cervix Carcinoma

3. Ipsilateral in situ ductal carcinoma

4. In situ lobular in situ carcinoma

5. Any other carcinoma without evidence disease in last 10 years

- Treatment chronic with corticoids (except patients starting 6 months before inclusion
with low dosages (* 20 mg methylprednisolone or equivalent)

- Concomitant treatment with Hormone ovarian replacement therapy

- Contraindication for corticoids

- Concomitant treatment with another investigational drugs

- Included in another clinical trial with any drug in 30 days before inclusion study

- Concomitant treatment with another anticancer therapy

- Male patients

- Hypersensibility to any study drug or components