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Altered Gene Expression in Colorectal "Smears" of Individuals With Colon Cancer


N/A
50 Years
N/A
Open (Enrolling by invite only)
Both
Colorectal Cancer Screening

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Trial Information

Altered Gene Expression in Colorectal "Smears" of Individuals With Colon Cancer


Inclusion Criteria:



- willing to provide informed consent

- greater than or equal to 50 years of age

- patient is scheduled for routine colonoscopy procedure or colorectal cancer surgery

- subject is willing to provide colorectal mucosal sample for gene expression testing

Exclusion Criteria:

- recent radiation or treatment for gynecologic, prostate or rectal cancer

- recent surgery for anal rectal disease

- polys, family or self history of cancer (control group only)

- GI disease

- any mucosal disease or systemic condition that may confound the scientific
interpretation of the gene expression results

Type of Study:

Observational

Study Design:

Observational Model: Case Control, Time Perspective: Prospective

Outcome Measure:

- To select a threshold for Mahalanobis distance to determine the best operating characteristics (sensitivity and specificity) in subjects with cancer and subjects without cancer. - To explore other empirical metrics based on previous exploratory data

Outcome Time Frame:

Mai 2009

Safety Issue:

No

Authority:

United States: Institutional Review Board

Study ID:

IGS-08-001

NCT ID:

NCT00720993

Start Date:

August 2008

Completion Date:

May 2009

Related Keywords:

  • Colorectal Cancer Screening
  • Colorectal cancer screening
  • Gene expression
  • RTPCR
  • Colorectal Neoplasms

Name

Location

Mayo ClinicRochester, Minnesota  55905