Molecular Analysis of Retinoblastoma
This is a biology protocol with no treatment regimen associated. Following routine
enucleation of the retinoblastoma affected eye, a portion of the tumor will be removed and
flash frozen and sent to St. Jude for RNA and DNA analysis. Some tissue will undergo
histopathological analysis and tissue microarrays will be isolated.
Observational Model: Case-Only, Time Perspective: Prospective
Identify genes exhibiting differential expression within intraocular disease tissue between patients having only intraocular involvement and those having extraocular involvement.
Rachel Brennan, MD
St. Jude Children's Research Hospital
United States: Institutional Review Board