Molecular Analysis of Retinoblastoma
N/A
N/A
Both
Retinoblastoma
Trial Information
Molecular Analysis of Retinoblastoma
This is a biology protocol with no treatment regimen associated. Following routine
enucleation of the retinoblastoma affected eye, a portion of the tumor will be removed and
flash frozen and sent to St. Jude for RNA and DNA analysis. Some tissue will undergo
histopathological analysis and tissue microarrays will be isolated.
Inclusion Criteria:
- Must have clinical diagnosis of retinoblastoma (to be confirmed histologically after
enucleation)
- Legal guardians must willing to sign an informed consent indicating that they are
aware of this study and its possible benefits. Legal guardians will be given a copy
of the consent form.
- Patient is being seen at this AHOPCA institution:
Exclusion Criteria:
- Ophthalmologist or oncologist is concerned that sampling will interfere with staging.
- Diagnosis other than retinoblastoma.
- Affiliated hospital is unable to provide pathologic evidence of retinoblastoma.
Type of Study:
Observational
Study Design:
Observational Model: Case-Only, Time Perspective: Prospective
Outcome Measure:
Identify genes exhibiting differential expression within intraocular disease tissue between patients having only intraocular involvement and those having extraocular involvement.
Outcome Time Frame:
Indefinite
Safety Issue:
No
Principal Investigator
Rachel Brennan, MD
Investigator Role:
Principal Investigator
Investigator Affiliation:
St. Jude Children's Research Hospital
Authority:
United States: Institutional Review Board
Study ID:
MARB
NCT ID:
NCT00718783
Start Date:
April 2007
Completion Date:
April 2013
Related Keywords:
- Retinoblastoma
- Retinoblastoma
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