Molecular Analysis of Retinoblastoma
This is a biology protocol with no treatment regimen associated. Following routine
enucleation of the retinoblastoma affected eye, a portion of the tumor will be removed and
flash frozen and sent to St. Jude for RNA and DNA analysis. Some tissue will undergo
histopathological analysis and tissue microarrays will be isolated.
- Must have clinical diagnosis of retinoblastoma (to be confirmed histologically after
- Legal guardians must willing to sign an informed consent indicating that they are
aware of this study and its possible benefits. Legal guardians will be given a copy
of the consent form.
- Patient is being seen at this AHOPCA institution:
- Ophthalmologist or oncologist is concerned that sampling will interfere with staging.
- Diagnosis other than retinoblastoma.
- Affiliated hospital is unable to provide pathologic evidence of retinoblastoma.
Type of Study:
Observational Model: Case-Only, Time Perspective: Prospective
Identify genes exhibiting differential expression within intraocular disease tissue between patients having only intraocular involvement and those having extraocular involvement.
Outcome Time Frame:
Rachel Brennan, MD
St. Jude Children's Research Hospital
United States: Institutional Review Board