Inclusion Criteria:

1. ≥ 18-year-old females

2. Histologically or cytologically documented invasive breast cancer

3. Documented progressive disease (Phase 1b study) OR documented metastatic disease
(Phase 2a study)

4. Prior Treatment:

- Phase 1b study: No more than 4 prior chemotherapy treatments, only 1 prior
taxane-based regimen for metastatic disease. There is no limit to the number of
prior hormonal or biological treatments.

- Phaes 2a study: No prior chemotherapy or biological therapy for metastatic
breast cancer. There is no limit to the number of prior hormonal treatments.

- Prior adjuvant chemotherapy or biological therapy will not be counted in the
number of prior treatments, unless recurrence occurs within 12 months of last
dose of adjuvant therapy, in which case it will be counted as 1 prior therapy;
adjuvant treatment with a taxane is allowed.

5. Measurable or evaluable disease by RECIST criteria (Phase 1b study) (see Appendix A).
Subjects to be enrolled in the Phase 2a study are required to have measureable
disease according to RECIST.

6. No prior VEGF-TKI drugs such as sunitinib, sorafenib, AZ2171, AG013736, GW786034,
ZD6474 AMG706, PTK/ZK and other similar agents.

7. No treatment with bevacizumab within 4 weeks prior to start of protocol therapy, no
prior treatment with other VEGF binding antibodies or VEGF-trap.

8. No treatment with the following agents within 3 weeks prior to start of protocol
therapy:

- Chemotherapy (at least 6 weeks for nitrosoureas, mitomycin C, and liposomal
doxorubicin)

- Other signal transduction inhibitors and monoclonal antibodies

- Immunotherapy or biological response modifiers

- Any experimental therapy

9. No treatment with radiotherapy within 2 weeks (if involving < 25% of bone marrow), or
4 weeks (if involving ≥ 25% of bone marrow) prior to start of protocol therapy.

10. Resolution of all toxicities

11. ECOG performance status ≤ 2 and life expectancy ≥ 3 months.

12. Signed and dated written informed consent

Exclusion Criteria:

1. Known hypersensitivity to paclitaxel or to any other component of the paclitaxel
formulation

2. Pregnant or lactating women; all fertile subjects must use effective contraception
(barrier method) while on study and for 3 months thereafter. All subjects must agree
to use a highly effective method of contraception (including their partner).
Effective birth control includes (a) IUD plus 1 barrier method, or (b) 2 barrier
methods. Effective barrier methods are male or female condoms, diaphragms, and
spermicides (creams or gels that contain a chemical to kill sperm.) Oral,
implantable, or injectable contraceptives may be affected by cytochrome P450
interactions, and are not considered effective for this study.

3. Subjects with symptomatic CNS metastases. Subjects with treated brain metastases that
have remained stable for at least 3 months without steroids are allowed. Subjects
with signs or symptoms or history of brain metastasis must have a CT or MRI scan of
the brain within 1 month prior to the start of protocol therapy. Subjects with spinal
cord or nerve root compression who have completed treatment at least 4 weeks before
the start of protocol therapy and are stable without steroid treatment for at least
one week before start of protocol therapy are allowed. Subjects with leptomeningeal
metastases are not allowed.

4. Any of the following hematologic abnormalities:

- Hemoglobin < 9.0 g/dL

- ANC < 1500 per mm3

- Platelet count < 100,000 per mm3

5. Any of the following serum chemistry abnormalities:

- Total bilirubin > 1.5 × ULN (>2.5 mg/dL in patients with Gilbert's syndrome)

- AST or ALT > 2.5 × ULN (or > 5 × ULN for subjects with liver metastasis)

- GGT > 2.5 x ULN (or > 5 × ULN for subjects with liver metastasis)

- Alkaline phosphatase > 2.5 × ULN (or > 5 × ULN for subjects with liver or bone
metastasis)

- Serum albumin < 3.0 g/dL

- Serum creatinine > 1.5 × ULN

- Proteinuria > 2.5 g/24 hours or 3+ with urine dipstick

- Any other ≥ Grade 3 laboratory abnormality at baseline (other than those listed
above)

6. Significant cardiovascular disease, including:

- Clinically symptomatic heart failure. Subjects with a history of heart failure
must have an ECHO or MUGA scan to document left ventricular ejection fraction
(LVEF) > 45% prior to start of protocol therapy

- Uncontrolled hypertension: Blood pressure >140/90 mm Hg on more than 2
antihypertensive medications, on two consecutive measurements obtained at least
24 hours apart. Subjects with a history of hypertension must have been on stable
doses of anti-hypertensive drugs for ≥ 2 weeks prior to start of protocol
therapy.

- Myocardial infarction within 3 months prior to start of protocol therapy

7. Baseline neuropathy > Grade 1

8. Subjects with delayed healing of wounds, ulcers, and/or bone fractures

9. Serious/active infection or infection requiring parenteral antibiotics

10. Inadequate recovery from any prior surgical procedure; major surgical procedure
within 6 weeks prior to start of protocol therapy.

11. Inability to comply with protocol requirements

12. Ongoing hemoptysis or history of clinically significant bleeding within 6 months
prior to start of protocol therapy

13. Cerebrovascular accident within 12 months to start of protocol therapy, or peripheral
vascular disease with claudication on walking less than 1 block.

14. Deep venous thrombosis or pulmonary embolus within 6 months prior to start of
protocol therapy

15. Subjects with a "currently active" second primary malignancy other than non-melanoma
skin cancers. Subjects are not considered to have a "currently active" malignancy if
they have completed anti-cancer therapy and have been disease free for > 2 years.

16. Known concomitant genetic or acquired immune suppression disease such as HIV

17. Treatment with systemic hormonal therapy within 3 weeks prior to start of or during
protocol therapy, with the exception of:

- Hormonal therapy for appetite stimulation or contraception

- Nasal, ophthalmic, inhaled and topical steroid preparations

- Oral replacement therapy for adrenal insufficiency

- Low-dose maintenance steroid therapy (equivalent of prednisone 10mg/day) for
other conditions

- Hormone replacement therapy

18. Herbal preparations/supplements (except for a daily multivitamin/mineral supplement
not containing herbal components) or CYP3A4 inhibitors within 2 weeks prior to start
of or during protocol therapy.

19. Full dose oral anticoagulation with warfarin, acenocoumarol, fenprocoumon, or similar
agents. If previously receiving these type of agents, a minimum washout of 1 week and
documented INR < 1.5 x ULN will be required prior to start of protocol therapy. Full
dose anti-coagulation with low molecular weight heparin or unfractionated heparin
administered subcutaneously is allowed.