Inclusion Criteria:

- adult patients, >=18 years of age;

- single organ recipients of liver allograft;

- CNI-based immunosuppressive regimen prior to study entry and regimen adjustment;

- >=6 months post-transplant, with renal dysfunction (serum creatinine
140-300micromol/L at entry);

- negative pregnancy test for women of childbearing potential; contraception must be
taken before beginning study drug therapy and until 6 weeks after last dose of study
medication.

Exclusion Criteria:

- treatment with CellCept or any other product which delivers mycophenolic acid within
the 3 months prior to the recent switch to CellCept relevant for enrollment;

- known contraindications to CNI, corticosteroids or CellCept.