Inclusion Criteria:

- Age ≥ 18

- Histologically proved cutaneous BCC

- Categorized as "bad prognostic" according to the 2004 recommendations of ANAES

1. morpheaform or ill-limited clinical forms and histologically aggressive forms
(morpheaform, micronodular, infiltrating, squamous differentiation) OR

2. already recurred BCC (except for superficial BCCs) OR

3. nodular BCCs from the high-risk zone (nose and peri-orificial areas of the head)
and with diameter larger than 1 cm.

- Life expectancy greater than 3 years according to the investigator's opinion.

- Patient being informed and having signed the consent to participate to the study

Exclusion Criteria:

- History of X-ray therapy in the territory of the BCC

- Counter-indication to surgery

- Life expectancy < 3 years

- superficial BCCs, even if recurred

- Patient being unable to attend future follow-up visits

- Patient with severe cognitive impairment

- Patient not affiliated to a social security regimen