Observational Study of Delayed Nausea and Vomiting Following Administration of Carboplatin Containing Regimens for Treatment of Cancer
All patients will be given the Functional Living Index- Emesis (FLIE), a standardized
questionnaire. This is a self-administered questionnaire to assess the impact of nausea and
vomiting on the patient's functional living, including physical activities, social and
emotional function, and ability to enjoy food and drink. Patients will complete the
questionnaire during the 5 days following carboplatin administration (at 24 hours, 48 hours,
72 hours and 96 hours) during their first and third cycles of chemotherapy. The
questionnaire should take approximately 10 minutes or less to complete.
Patients will also be interviewed by a trained CRA or research nurse over the telephone
24-48 hours following carboplatin administration in order to assess the severity of the
delayed nausea and vomiting.
Time Perspective: Prospective
Characterize the incidence of delayed emesis following administration of carboplatin-containing chemotherapy regimens
Despite appropriate administration of standard 5-HT3 receptor antagonist antiemetic prophylaxis after the first cycle of chemotherapy.
After 1st cycle of chemotherapy
Maria Q Baggstrom, M.D.
Washington University School of Mecicine
United States: Institutional Review Board
06-0981 / 201104043
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