Partial Breast Irradiation (PBI) for Selected Patients With Early Invasive or Non-Invasive Breast Cancer: A Phase I Feasibility/Pilot Study
- In this study, radiotherapy is given only to a portion of the breast around the tumor
bed using external radiation treatments. This approach is called "partial breast
- Participants will undergo a planning session for the radiation treatments. This
planning will be done by CT scan days or weeks before the start of treatment. This
planning process is the same as that used to plan conventional radiation therapy
- Radiation therapy will begin 4-12 weeks after the last surgery of the breast in
individuals not receiving chemotherapy first. For individuals receiving chemotherapy
before radiation therapy, radiation therapy will start 2-6 weeks after ending
- We will be studying three levels of radiation doses to see which is best. The dose the
participant receives will depend upon when they are enrolled on the trial.
- Participants will receive radiation treatment twice each day for 4 or 5 treatment days,
with an overall treatment time of one week.
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
To evaluate the feasibility of PBI directed XRT in selected stages 0 and 1 female breast cancer patients within each dose level.
Alphonse Taghian, MD, PhD
Massachusetts General Hospital
United States: Institutional Review Board
|Beth Israel Deaconess Medical Center||Boston, Massachusetts 02215|
|Dana-Farber Cancer Institute||Boston, Massachusetts 02115|
|Boston Medical Center||Boston, Massachusetts 02118|
|Massachusetts General Hospital||Boston, Massachusetts 02114-2617|